DataVXAdvanced MaterialsPaper
journal article·2016-09Open access

Self‐Sealing Porous Silicon‐Calcium Silicate Core–Shell Nanoparticles for Targeted siRNA Delivery to the Injured Brain

Jinyoung Kang, Jinmyoung Joo, Ester J. Kwon, Matthew Skalak, Sazid Hussain, Zhi‐Gang She, Erkki Ruoslahti, Sangeeta N. Bhatia, Michael J. Sailor

Advanced Materials· Volume 28· Issue 36
Publisher pageOpen full text
Source abstract

Abstract

Calcium ions react with silicic acid released from dissolving porous silicon nanoparticles to create an insoluble calcium silicate shell. The calcium silicate shell traps and protects an siRNA payload, which can be delivered to neuronal tissues in vitro or in vivo. Gene delivery is enhanced by the action of targeting and cell-penetrating peptides attached to the calcium silicate shell.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · Silicon Nanostructures and Photoluminescence

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Nanoengineering University of California San Diego La Jolla CA 92093‐0358 USA

Department of Chemistry and Biochemistry University of California San Diego La Jolla CA 92093‐0358 USA

Harvard‐MIT Division of Health Sciences and Technology Massachusetts Institute of Technology Cambridge MA 02139 USA

Cancer Center Sanford Burnham Prebys Medical Discovery Institute La Jolla CA 92037 USA

Center for Nanomedicine and Department of Molecular Cellular and Developmental Biology University of California, Santa Barbara Santa Barbara CA 93106‐9610 USA

Department of Electrical Engineering and Computer Science and David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology Cambridge MA 02139 USA

Division of Medicine Brigham and Women's Hospital Boston MA 02115 USA

Howard Hughes Medical Institute Cambridge MA 02139 USA

Department of Bioengineering Materials Science and Engineering Program University of California San Diego 9500 Gilman Drive m/c 0358 La Jolla CA 92093‐0358 USA

Funding

National Science Foundation · Defense Advanced Research Projects Agency

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