DataVXAdvanced MaterialsPaper
journal article·2016-06

Tunable Thermal‐Sensitive Polymer–Graphene Oxide Composite for Efficient Capture and Release of Viable Circulating Tumor Cells

Hyeun Joong Yoon, Apoorv Shanker, Yang Wang, Molly Kozminsky, Qu Jin, Nallasivam Palanisamy, Monika L. Burness, Ebrahim Azizi, Diane M. Simeone, Max S. Wicha, Jinsang Kim, Sunitha Nagrath

Advanced Materials· Volume 28· Issue 24
Publisher page
Source abstract

Abstract

A highly sensitive microfluidic system to capture circulating tumor cells from whole blood of cancer patients is presented. The device incorporates graphene oxide into a thermoresponsive polymer film to serve as the first step of an antibody functionalization chemistry. By decreasing the temperature, captured cells may be released for subsequent analysis. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
Source: openalex_inverted_index · Quality: baseline

Research context

PolymersNanomaterialsComposites

OpenAlex topics: Graphene and Nanomaterials Applications · 3D Printing in Biomedical Research · Cancer Cells and Metastasis

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical Engineering University of Michigan 2300 Hayward Street Ann Arbor MI 48109 USA

Department of Electrical Engineering and Computer Science South Dakota State University Brookings SD 57007 USA

Biointerfaces Institute University of Michigan 2800 Plymouth Road Ann Arbor MI 48109 USA

Translational Oncology Program University of Michigan Health System 1600 Huron Pkwy Ann Arbor MI 48109 USA

Macromolecular Science and Engineering University of Michigan 2300 Hayward Street Ann Arbor MI 48109 USA

Henry Ford Health System 1 Ford Place Detroit MI 48202 USA

Department of Internal Medicine University of Michigan Comprehensive Cancer Center 1500 E. Medical Center Drive Ann Arbor MI 48109 USA

Department of Material Science and Engineering Department of Biomedical Engineering Department of Chemistry University of Michigan 2300 Hayward Street Ann Arbor MI 48109 USA

Funding

National Science Foundation

References (45)

Show source-provided references
1. 10.1038/nnano.2014.31110.1038/nnano.2014.311 ↗
2. 10.1016/j.cell.2006.11.00110.1016/j.cell.2006.11.001 ↗
3. 10.1016/j.gde.2009.12.00210.1016/j.gde.2009.12.002 ↗
4. 10.1016/j.canlet.2006.12.01410.1016/j.canlet.2006.12.014 ↗
5. 10.1038/nrc382010.1038/nrc3820 ↗
6. 10.1038/nature0638510.1038/nature06385 ↗
7. Gleghorn J. P. · LabChip · 2010 · 10 · 27
8. 10.1021/nn500427710.1021/nn5004277 ↗
9. 10.1007/s10544-012-9734-810.1007/s10544-012-9734-8 ↗
10. 10.18632/oncotarget.259210.18632/oncotarget.2592 ↗
11. 10.1073/pnas.101253910710.1073/pnas.1012539107 ↗
12. 10.1021/ja801502210.1021/ja8015022 ↗
13. 10.1021/ac401720k10.1021/ac401720k ↗
14. 10.1016/j.nantod.2013.07.00110.1016/j.nantod.2013.07.001 ↗
15. 10.1007/s12274-008-8021-810.1007/s12274-008-8021-8 ↗
16. 10.1002/anie.20100142810.1002/anie.201001428 ↗
17. 10.1016/j.biomaterials.2011.01.00210.1016/j.biomaterials.2011.01.002 ↗
18. 10.1038/nnano.2013.19410.1038/nnano.2013.194 ↗
19. 10.1016/S0168-3659(99)00150-910.1016/S0168-3659(99)00150-9 ↗
20. 10.1002/jbm.a.3109810.1002/jbm.a.31098 ↗
21. 10.1021/bm000094510.1021/bm0000945 ↗
22. 10.1023/A:100562242482110.1023/A:1005622424821 ↗
23. 10.1126/science.108075910.1126/science.1080759 ↗
24. 10.1002/adma.20120318510.1002/adma.201203185 ↗
25. 10.1002/adma.20120382610.1002/adma.201203826 ↗
26. 10.1021/la105016a10.1021/la105016a ↗
27. 10.1021/ac300190j10.1021/ac300190j ↗
28. 10.1002/adma.20140467710.1002/adma.201404677 ↗
29. 10.1021/nn505628210.1021/nn5056282 ↗
30. 10.1002/adma.20120382610.1002/adma.201203826 ↗
31. 10.1080/03602559.2012.75141010.1080/03602559.2012.751410 ↗
32. 10.1021/nn100003510.1021/nn1000035 ↗
33. 10.1002/adma.20090346910.1002/adma.200903469 ↗
34. 10.1021/jp102640s10.1021/jp102640s ↗
35. 10.1039/c1cc00075f10.1039/c1cc00075f ↗
36. 10.1021/bc200397j10.1021/bc200397j ↗
37. 10.1002/adma.20110407010.1002/adma.201104070 ↗
38. 10.1021/am507973210.1021/am5079732 ↗
39. 10.1088/1758-5090/7/1/01500910.1088/1758-5090/7/1/015009 ↗
40. 10.1002/app.4180910.1002/app.41809 ↗
41. 10.1016/j.cej.2015.01.10510.1016/j.cej.2015.01.105 ↗
42. 10.1002/(SICI)1097-0290(19981205)60:5<568::AID-BIT7>3.0.CO;2-V10.1002/(SICI)1097-0290(19981205)60:5<568::AID-BIT7>3.0.CO;2-V ↗
43. 10.1021/la052507z10.1021/la052507z ↗
44. 10.1158/0008-5472.CAN-12-334910.1158/0008-5472.CAN-12-3349 ↗
45. Arya S. K. · LabChip · 2013 · 13 · 1995