journal article·2019-08

Efficient Delivery of Nerve Growth Factors to the Central Nervous System for Neural Regeneration

Duo Xu, Di Wu, Meng Qin, Lina R. Nih, Chaoyong Liu, Zheng Cao, Jie Ren, Xiangjun Chen, Zhanlong He, Wenhai Yu, Jiaoqiong Guan, Suqin Duan, Fang Liu, Xiangsheng Liu, Jesse Li, Dushawn Harley, Bin Xu, Lihua Hou, Irvin S. Y. Chen, Jing Wen, Wei Chen, Sina Pourtaheri, Yunfeng Lu

Advanced Materials· Volume 31· Issue 33
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Abstract

Abstract The central nervous system (CNS) plays a central role in the control of sensory and motor functions, and the disruption of its barriers can result in severe and debilitating neurological disorders. Neurotrophins are promising therapeutic agents for neural regeneration in the damaged CNS. However, their penetration across the blood–brain barrier remains a formidable challenge, representing a bottleneck for brain and spinal cord therapy. Herein, a nanocapsule‐based delivery system is reported that enables intravenously injected nerve growth factor (NGF) to enter the CNS in healthy mice and nonhuman primates. Under pathological conditions, the delivery of NGF enables neural regeneration, tissue remodeling, and functional recovery in mice with spinal cord injury. This technology can be utilized to deliver other neurotrophins and growth factors to the CNS, opening a new avenue for tissue engineering and the treatment of CNS disorders and neurodegenerative diseases.
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Research context

OpenAlex topics: Nerve injury and regeneration · Neurogenesis and neuroplasticity mechanisms · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical and Biomolecular Engineering University of California, Los Angeles Los Angeles CA 90095 USA

Department of Microbiology, Immunology, and Molecular Genetics UCLA AIDS Institute University of California, Los Angeles Los Angeles CA 90095 USA

College of Life Science and Technology Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Biotechnology Beijing 100029 China

Department of Neurology Huashan Hospital Shanghai 200040 China

Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming Yunnan 650118 China

California NanoSystem Institute Los Angeles CA 90095 USA

Department of Orthopaedic Surgery University of California Los Angeles CA 90095 USA

State Key Laboratory of Supramolecular Structure and Materials Jilin University Changchun Jilin 130012 China

Beijing Institute of Biotechnology Beijing 100029 China

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