journal article·2016-10Open access

Renal Clearable Organic Nanocarriers for Bioimaging and Drug Delivery

Homan Kang, Julien Gravier, Kai Bao, Hideyuki Wada, Jeong Heon Lee, Yoonji Baek, Georges El Fakhri, Sylvain Gioux, Brian P. Rubin, Jean‐Luc Coll, Hak Soo Choi

Advanced Materials· Volume 28· Issue 37

Abstract

Renally cleared zwitterionic nanocarriers (H-Dots) are composed of ε-polylysine backbone for charge variations, near-infrared fluorophores for bioimaging, and β-cyclodextrins for potential drug delivery. H-Dots show ideal systemic circulation and rapid distribution and excrete from normal tissue/organ via renal excretion after complete targeting to the tumor site without nonspecific uptake by the immune system. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Nanocluster Synthesis and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Division of Hematology/Oncology Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA 02215 USA

Institut Albert Bonniot Université Grenoble Alpes Grenoble F‐38000 France

INSERM U1209 Grenoble F‐38000 France

Departments of Anatomic Pathology and Cancer Biology Robert J. Tomsich Pathology and Laboratory Medicine Institute Lerner Research Institute and Taussig Cancer Center Cleveland Clinic Cleveland OH 44195 USA

Funding

European Project FP7 · NIH/NIBIB · France Live Imaging · Basic Science Research Program

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