DataVXAdvanced MaterialsPaper
journal article·2024-07

Ultrasound‐Responsive Aligned Piezoelectric Nanofibers Derived Hydrogel Conduits for Peripheral Nerve Regeneration

Dongyu Xu, Siqi Fu, Hui Zhang, Weicheng Lu, Jingdun Xie, Jilai Li, Huan Wang, Yuanjin Zhao, Renjie Chai

Advanced Materials· Volume 36· Issue 28
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Source abstract

Abstract

Abstract Nerve guidance conduits (NGCs) are considered as promising treatment strategy and frontier trend for peripheral nerve regeneration, while their therapeutic outcomes are limited by the lack of controllable drug delivery and available physicochemical cues. Herein, novel aligned piezoelectric nanofibers derived hydrogel NGCs with ultrasound (US)‐triggered electrical stimulation (ES) and controllable drug release for repairing peripheral nerve injury are proposed. The inner layer of the NGCs is the barium titanate piezoelectric nanoparticles (BTNPs)‐doped polyvinylidene fluoride‐trifluoroethylene [BTNPs/P(VDF‐TrFE)] electrospinning nanofibers with improved piezoelectricity and aligned orientation. The outer side of the NGCs is the thermoresponsive poly(N‐isopropylacrylamide) hybrid hydrogel with bioactive drug encapsulation. Such NGCs can not only induce neuronal‐oriented extension and promote neurite outgrowth with US‐triggered wireless ES, but also realize the controllable nerve growth factor release with the hydrogel shrinkage under US‐triggered heating. Thus, the NGC can positively accelerate the functional recovery and nerve axonal regeneration of rat models with long sciatic nerve defects. It is believed that the proposed US‐responsive aligned piezoelectric nanofibers derived hydrogel NGCs will find important applications in clinic neural tissue engineering.
Source: crossref · Quality: baseline

Research context

PolymersNanomaterialsBiomaterials

OpenAlex topics: Nerve injury and regeneration · Electrospun Nanofibers in Biomedical Applications · Neurogenesis and neuroplasticity mechanisms

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Digital Medical Engineering Department of Otolaryngology Head and Neck Surgery Zhongda Hospital School of Life Sciences and Technology School of Medicine Advanced Institute for Life and Health Jiangsu Province High‐Tech Key Laboratory for Bio‐Medical Research Southeast University Nanjing 210096 China

Department of Rheumatology and Immunology Nanjing Drum Tower Hospital School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China

Co‐Innovation Center of Neuroregeneration Nantong University Nantong 226001 China

Japan Friendship School of Clinical Medicine Peking University Beijing 100029 China

Department of Anesthesiology State Key Laboratory of Oncology in South China Sun Yat‐sen University Cancer Center Guangzhou 510060 P. R. China

Department of Neurology Aerospace Center Hospital Peking University Aerospace Clinical College Beijing 100049 China

The Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen 518033 China

Department of Neurology Aerospace Center Hospital School of Life Science Beijing Institute of Technology Beijing 100081 China

Department of Otolaryngology Head and Neck Surgery Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu 610072 China

Southeast University Shenzhen Research Institute Shenzhen 518063 China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Jiangsu Province · Science and Technology Department of Sichuan Province · National Key Research and Development Program of China

References (40)

Show source-provided references
1. 10.1038/s41583-018-0001-810.1038/s41583-018-0001-8 ↗
2. 10.1016/j.cell.2021.10.02910.1016/j.cell.2021.10.029 ↗
3. 10.1038/nrneurol.2013.22710.1038/nrneurol.2013.227 ↗
4. 10.1016/j.actbio.2020.02.00310.1016/j.actbio.2020.02.003 ↗
5. 10.1002/advs.20210387510.1002/advs.202103875 ↗
6. 10.1021/acsnano.1c1162710.1021/acsnano.1c11627 ↗
7. 10.1021/acsnano.0c0357010.1021/acsnano.0c03570 ↗
8. 10.1002/sstr.20230004510.1002/sstr.202300045 ↗
9. 10.1016/j.biomaterials.2020.12016410.1016/j.biomaterials.2020.120164 ↗
10. 10.1016/j.matt.2023.03.00510.1016/j.matt.2023.03.005 ↗
11. 10.1007/s40820-021-00751-y10.1007/s40820-021-00751-y ↗
12. 10.1002/advs.20220753610.1002/advs.202207536 ↗
13. 10.1016/j.biomaterials.2021.12099710.1016/j.biomaterials.2021.120997 ↗
14. 10.1038/s41587-020-0495-210.1038/s41587-020-0495-2 ↗
15. 10.1038/s41551-020-0518-910.1038/s41551-020-0518-9 ↗
16. 10.1126/sciadv.150147810.1126/sciadv.1501478 ↗
17. 10.1021/acs.chemrev.8b0059310.1021/acs.chemrev.8b00593 ↗
18. 10.1021/acsnano.0c0452710.1021/acsnano.0c04527 ↗
19. 10.1002/adfm.20160461710.1002/adfm.201604617 ↗
20. 10.1016/j.msec.2020.11075610.1016/j.msec.2020.110756 ↗
21. 10.1016/j.biomaterials.2019.11955510.1016/j.biomaterials.2019.119555 ↗
22. 10.1002/adfm.20180689910.1002/adfm.201806899 ↗
23. 10.1016/j.mtchem.2022.10094410.1016/j.mtchem.2022.100944 ↗
24. 10.1126/sciadv.abc668610.1126/sciadv.abc6686 ↗
25. 10.1016/j.nanoen.2022.10732210.1016/j.nanoen.2022.107322 ↗
26. 10.1002/aenm.20210132910.1002/aenm.202101329 ↗
27. 10.1002/adma.20200380010.1002/adma.202003800 ↗
28. 10.1016/j.nanoen.2022.10770710.1016/j.nanoen.2022.107707 ↗
29. 10.1002/SMMD.2023000210.1002/SMMD.20230002 ↗
30. 10.1002/aenm.20190276910.1002/aenm.201902769 ↗
31. 10.1021/acsami.8b1982410.1021/acsami.8b19824 ↗
32. 10.1016/j.nanoen.2020.10551510.1016/j.nanoen.2020.105515 ↗
33. 10.1002/adfm.20211074610.1002/adfm.202110746 ↗
34. 10.1002/advs.20180155510.1002/advs.201801555 ↗
35. 10.1002/advs.20230090210.1002/advs.202300902 ↗
36. 10.1016/j.engreg.2021.03.00210.1016/j.engreg.2021.03.002 ↗
37. Huang D. · Innovation · 2023 · 4
38. 10.1002/pol.1975.17013111310.1002/pol.1975.170131113 ↗
39. 10.1016/j.pmatsci.2020.10070210.1016/j.pmatsci.2020.100702 ↗
40. 10.1002/adhm.20200224910.1002/adhm.202002249 ↗