journal article·2022-09Open access

Reactive Oxygen Species Scavenging Nanomedicine for the Treatment of Ischemic Heart Disease

Zhan Zhang, Rinkoo Dalan, Zhenyu Hu, Jiong‐Wei Wang, Nicholas WS Chew, Kian‐Keong Poh, Ru‐San Tan, Tuck Wah Soong, Yunlu Dai, Lei Ye, Xiaoyuan Chen

Advanced Materials· Volume 34· Issue 35

Abstract

Abstract Ischemic heart disease (IHD) is the leading cause of disability and mortality worldwide. Reactive oxygen species (ROS) have been shown to play key roles in the progression of diabetes, hypertension, and hypercholesterolemia, which are independent risk factors that lead to atherosclerosis and the development of IHD. Engineered biomaterial‐based nanomedicines are under extensive investigation and exploration, serving as smart and multifunctional nanocarriers for synergistic therapeutic effect. Capitalizing on cell/molecule‐targeting drug delivery, nanomedicines present enhanced specificity and safety with favorable pharmacokinetics and pharmacodynamics. Herein, the roles of ROS in both IHD and its risk factors are discussed, highlighting cardiovascular medications that have antioxidant properties, and summarizing the advantages, properties, and recent achievements of nanomedicines that have ROS scavenging capacity for the treatment of diabetes, hypertension, hypercholesterolemia, atherosclerosis, ischemia/reperfusion, and myocardial infarction. Finally, the current challenges of nanomedicines for ROS‐scavenging treatment of IHD and possible future directions are discussed from a clinical perspective.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Nanoparticle-Based Drug Delivery · Advanced Nanomaterials in Catalysis · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Cancer Centre and Institute of Translational Medicine Faculty of Health Sciences University of Macau Taipa Macau SAR 999078 China

Department of Endocrinology Tan Tock Seng Hospital Lee Kong Chian School of Medicine Nanyang Technological University Singapore 408433 Singapore

Department of Physiology Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Cardiovascular Research Institute Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Department of Diagnostic Radiology and Department of Surgery Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Nanomedicine Translational Research Programme Centre for NanoMedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Department of Cardiology National University Heart Centre National University Hospital Singapore 119074 Singapore

Department of Cardiology National Heart Centre Singapore Singapore 119609 Singapore

MoE Frontiers Science Center for Precision Oncology University of Macao Taipa Macau SAR 999078 China

Department of Biomedical Engineering University of Alabama at Birmingham Birmingham AL 35294 USA

Department of Chemical and Biomolecular Engineering and Department of Biomedical Engineering Faculty of Engineering National University of Singapore Singapore 117597 Singapore

Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Funding

National Natural Science Foundation of China · National University of Singapore

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