Designing Stimuli‐Responsive Upconversion Nanoparticles that Exploit the Tumor Microenvironment
Source abstract
Abstract
Abstract Tailoring personalized cancer nanomedicines demands detailed understanding of the tumor microenvironment. In recent years, smart upconversion nanoparticles with the ability to exploit the unique characteristics of the tumor microenvironment for precise targeting have been designed. To activate upconversion nanoparticles, various bio‐physicochemical characteristics of the tumor microenvironment, namely, acidic pH, redox reactants, and hypoxia, are exploited. Stimuli‐responsive upconversion nanoparticles also utilize the excessive presence of adenosine triphosphate (ATP), riboflavin, and Zn2+ in tumors. An overview of the design of stimulus‐responsive upconversion nanoparticles that precisely target and respond to tumors via targeting the tumor microenvironment and intracellular signals is provided. Detailed understanding of the tumor microenvironment and the personalized design of upconversion nanoparticles will result in more effective clinical translation.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 P. R. China
School of Nanoscience and Technology University of Chinese Academy of Sciences Beijing 100049 P. R. China
Department of Bioengineering Rice University 6500 Main St Ste 1030 Houston TX 77030 USA
School of Biomedical Sciences Faculty of Biological Sciences University of Leeds Leeds LS2 9JT UK
Department of Biotechnology PSG College of Technology Coimbatore Tamil Nadu 641004 India
Department of Formulation R&D Aavishkar Oral Strips Pvt. Ltd. Cherlapally Hyderabad 500051 India
NILOP Nanomedicine Research Laboratories (NNRL) National Institute of Lasers and Optronics College Pakistan Institute of Engineering and Applied Sciences Lehtrar Road Islamabad 45650 Pakistan
Funding
National Natural Science Foundation of China
References (100+)
Show source-provided references
1. 10.1002/adfm.20130213310.1002/adfm.201302133 ↗
2. 10.1002/adma.20130443710.1002/adma.201304437 ↗
3. 10.1002/anie.20130883410.1002/anie.201308834 ↗
4. 10.1007/s11426-018-9397-510.1007/s11426-018-9397-5 ↗
5. 10.1039/C4CC08178A10.1039/C4CC08178A ↗
6. 10.1002/smll.20170380910.1002/smll.201703809 ↗
7. 10.1002/adma.20140514110.1002/adma.201405141 ↗
8. 10.1039/C5NR01932J10.1039/C5NR01932J ↗
9. 10.1016/j.nano.2017.03.00810.1016/j.nano.2017.03.008 ↗
10. 10.1039/C7NR03019C10.1039/C7NR03019C ↗
11. 10.1002/adfm.20160467110.1002/adfm.201604671 ↗
12. 10.1016/j.biomaterials.2016.06.03710.1016/j.biomaterials.2016.06.037 ↗
13. 10.7150/thno.2248210.7150/thno.22482 ↗
14. 10.1002/adma.20150328010.1002/adma.201503280 ↗
15. 10.1016/j.ccr.2014.01.00410.1016/j.ccr.2014.01.004 ↗
16. 10.1039/C1CS15187H10.1039/C1CS15187H ↗
17. 10.1002/adfm.20120173310.1002/adfm.201201733 ↗
18. 10.1021/cm103175s10.1021/cm103175s ↗
19. 10.1021/cm803151y10.1021/cm803151y ↗
20. 10.1021/la902260j10.1021/la902260j ↗
21. 10.1021/ja076151k10.1021/ja076151k ↗
22. 10.1039/c2nr30982c10.1039/c2nr30982c ↗
23. 10.1039/C4CS00158C10.1039/C4CS00158C ↗
24. 10.1038/s41591-018-0014-x10.1038/s41591-018-0014-x ↗
25. 10.1002/adma.20180830310.1002/adma.201808303 ↗
26. 10.7150/jca.1764810.7150/jca.17648 ↗
27. 10.1186/s12916-015-0278-710.1186/s12916-015-0278-7 ↗
28. 10.1016/j.cell.2011.02.01310.1016/j.cell.2011.02.013 ↗
29. 10.1016/j.canlet.2017.10.03710.1016/j.canlet.2017.10.037 ↗
30. 10.1016/j.nantod.2018.08.00710.1016/j.nantod.2018.08.007 ↗
31. 10.1016/j.jconrel.2010.08.02710.1016/j.jconrel.2010.08.027 ↗
32. 10.1016/j.tibtech.2016.07.00610.1016/j.tibtech.2016.07.006 ↗
33. 10.1097/PPO.000000000000012310.1097/PPO.0000000000000123 ↗
34. 10.1039/C9CS00309F10.1039/C9CS00309F ↗
35. 10.1038/nrc.2016.10810.1038/nrc.2016.108 ↗
36. Meel R. · 2017
37. 10.1021/acs.accounts.9b0022810.1021/acs.accounts.9b00228 ↗
38. 10.3390/ijms2004084010.3390/ijms20040840 ↗
39. 10.1016/j.jocit.2016.08.00210.1016/j.jocit.2016.08.002 ↗
40. 10.1016/j.biomaterials.2017.08.01010.1016/j.biomaterials.2017.08.010 ↗
41. 10.1002/adfm.20150158210.1002/adfm.201501582 ↗
42. 10.1038/s41598-017-16948-410.1038/s41598-017-16948-4 ↗
43. 10.1002/anie.20140951910.1002/anie.201409519 ↗
44. 10.1039/C7NR06874C10.1039/C7NR06874C ↗
45. 10.1039/C5BM00328H10.1039/C5BM00328H ↗
46. 10.1021/acsami.7b1419310.1021/acsami.7b14193 ↗
47. 10.7150/thno.3698810.7150/thno.36988 ↗
48. 10.1016/j.addr.2008.08.00310.1016/j.addr.2008.08.003 ↗
49. Koukourakis M. I. · Cancer Res. · 2001 · 61 · 1830
50. 10.1158/1535-7163.MCT-06-042110.1158/1535-7163.MCT-06-0421 ↗
51. 10.7150/thno.528410.7150/thno.5284 ↗
52. 10.1002/anie.20150047810.1002/anie.201500478 ↗
53. 10.1016/j.biomaterials.2017.02.01710.1016/j.biomaterials.2017.02.017 ↗
54. 10.1016/j.biomaterials.2015.01.02810.1016/j.biomaterials.2015.01.028 ↗
55. 10.1039/C5NR07887C10.1039/C5NR07887C ↗
56. 10.1089/ars.2017.738310.1089/ars.2017.7383 ↗
57. 10.1073/pnas.121329111010.1073/pnas.1213291110 ↗
58. 10.1021/nn405082y10.1021/nn405082y ↗
59. 10.1021/bc500396710.1021/bc5003967 ↗
60. 10.1002/adma.20130522210.1002/adma.201305222 ↗
61. 10.2967/jnumed.112.10804310.2967/jnumed.112.108043 ↗
62. 10.1101/cshperspect.a00647810.1101/cshperspect.a006478 ↗
63. 10.1021/ac901960d10.1021/ac901960d ↗
64. 10.1126/science.124.3215.26910.1126/science.124.3215.269 ↗
65. 10.1016/j.cell.2017.09.01910.1016/j.cell.2017.09.019 ↗
66. 10.1016/0309-1651(82)90125-410.1016/0309-1651(82)90125-4 ↗
67. 10.1021/nn403772j10.1021/nn403772j ↗
68. 10.1002/adhm.20130005110.1002/adhm.201300051 ↗
69. 10.1002/chem.20140438210.1002/chem.201404382 ↗
70. 10.1038/ncomms436410.1038/ncomms4364 ↗
71. 10.1002/anie.20140026810.1002/anie.201400268 ↗
72. 10.1158/0008-5472.CAN-11-167410.1158/0008-5472.CAN-11-1674 ↗
73. 10.1016/j.addr.2012.09.03610.1016/j.addr.2012.09.036 ↗
74. 10.1021/nn403722x10.1021/nn403722x ↗
75. 10.1002/anie.20140090010.1002/anie.201400900 ↗
76. 10.1002/adma.20130312410.1002/adma.201303124 ↗
77. 10.1021/cr400425h10.1021/cr400425h ↗
78. 10.2174/156652401366613111112213310.2174/1566524013666131111122133 ↗
79. 10.1021/acsnano.5b0064110.1021/acsnano.5b00641 ↗
80. 10.1038/nrm380110.1038/nrm3801 ↗
81. 10.1016/j.cell.2011.12.02710.1016/j.cell.2011.12.027 ↗
82. 10.1038/nature1390910.1038/nature13909 ↗
83. 10.1074/jbc.M11189920010.1074/jbc.M111899200 ↗
84. 10.1113/expphysiol.2006.03350610.1113/expphysiol.2006.033506 ↗
85. 10.1056/NEJMcibr140570110.1056/NEJMcibr1405701 ↗
86. 10.1038/nchembio.191010.1038/nchembio.1910 ↗
87. 10.1016/j.cmet.2016.08.01210.1016/j.cmet.2016.08.012 ↗
88. 10.1002/smll.20170380910.1002/smll.201703809 ↗
89. 10.1039/C7SC05414A10.1039/C7SC05414A ↗
90. 10.1002/adfm.20170062610.1002/adfm.201700626 ↗
91. 10.1002/adma.20170483310.1002/adma.201704833 ↗
92. 10.1016/j.biomaterials.2017.03.04110.1016/j.biomaterials.2017.03.041 ↗
93. 10.1021/cr900236h10.1021/cr900236h ↗
94. 10.1002/anie.20170114610.1002/anie.201701146 ↗
95. 10.1021/acs.chemrev.6b0052510.1021/acs.chemrev.6b00525 ↗
96. 10.1021/cr900300p10.1021/cr900300p ↗
97. 10.1039/B915149B10.1039/B915149B ↗
98. 10.1021/cr400532z10.1021/cr400532z ↗
99. 10.1016/S1572-1000(05)00110-910.1016/S1572-1000(05)00110-9 ↗
100. 10.1021/ac502103t10.1021/ac502103t ↗