DataVXAdvanced MaterialsPaper
journal article·2021-12

Promoting Oral Mucosal Wound Healing with a Hydrogel Adhesive Based on a Phototriggered S‐Nitrosylation Coupling Reaction

Wenjie Zhang, Bingkun Bao, Fei Jiang, Yiqing Zhang, Renjie Zhou, Yuezhi Lu, Sihan Lin, Qiuning Lin, Xinquan Jiang, Linyong Zhu

Advanced Materials· Volume 33· Issue 48
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Source abstract

Abstract

Abstract The wet and highly dynamic environment of the mouth makes local treatment of oral mucosal diseases challenging. To overcome this, a photo‐crosslinking hydrogel adhesive is developed inspired by the success of light‐curing techniques in dentistry. The adhesive operates on a fast (within 5 s) phototriggered S‐nitrosylation coupling reaction and employs imine anchoring to connect to host tissues. Unlike other often‐used clinical agents that adhere weakly and for short durations, this thin, elastic, adhesive, and degradable cyclic o‐nitrobenzyl‐modified hyaluronic acid gel protects mucosal wounds from disturbance by liquid rinsing, oral movement, and friction for more than 24 h. The results from both rat and pig oral mucosa repair models demonstrate that this new gel adhesive creates a favorable microenvironment for tissue repair and can shorten tissue healing time. This study thus illustrates a therapeutic strategy with the potential to advance the treatment of oral mucosal defects in the clinic.
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Research context

Polymers

OpenAlex topics: Antimicrobial agents and applications · Polydiacetylene-based materials and applications · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Prosthodontics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Engineering Research Center of Advanced Dental Technology and Materials 639 Zhizaoju Road Shanghai 200011 China

School of Biomedical Engineering Shanghai Jiao Tong University 800 Dong Chuan Road Shanghai 200240 China

Jiangsu Key Laboratory of Oral Diseases Department of General Dentistry Affiliated Hospital of Stomatology Nanjing Medical University No. 140, Han Zhong Road Nanjing 210029 P. R. China

Optogenetics & Synthetic Biology Interdisciplinary Research Center State Key Laboratory of Bioreactor Engineering Shanghai Collaborative Innovation Center for Biomanufacturing Technology East China University of Science and Technology 130 Mei Long Road Shanghai 200237 China

School of Chemistry and Molecular Engineering East China University of Science and Technology 130 Mei Long Road Shanghai 200237 China

Funding

National Key Research and Development Program of China · Shanghai Rising-Star Program · National Natural Science Foundation of China

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