DataVXAdvanced MaterialsPaper
journal article·2021-12

ZnS@BSA Nanoclusters Potentiate Efficacy of Cancer Immunotherapy

Dong Cen, Qiwei Ge, Congkun Xie, Qiang Zheng, Jiansheng Guo, Yuqi Zhang, Yifan Wang, Xiang Li, Zhen Gu, Xiujun Cai

Advanced Materials· Volume 33· Issue 49
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Source abstract

Abstract

Abstract Although immunotherapy such as immune checkpoint inhibitors has shown promising efficacy in cancer treatment, the responsiveness among patients is relatively limited. Activation of the cyclic guanosine monophosphate‐adenosine monophosphate synthase/interferon gene stimulator (cGAS/STING) signaling pathway to upregulate innate immunity has become an emerging strategy for enhancing tumor immunotherapy. Herein, ZnS@BSA (bovine serum albumin) nanoclusters synthesized via a self‐assembly approach are reported, where the released zinc ions under acidic tumor microenvironment significantly enhance cGAS/STING signals. Meanwhile, intracellular zinc ions can produce reactive oxygen species, which is further facilitated by the generated H2S gas from ZnS@BSA via specifically inhibiting catalase in hepatocellular carcinoma cells. It is found that the nanoclusters activate the cGAS/STING signals in mice, which promotes the infiltration of CD8+ T cells at the tumor site and cross‐presentation of dendritic cells, leading to an improved immunotherapy efficacy against hepatocellular carcinoma.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · RNA Interference and Gene Delivery · COVID-19 Impact on Reproduction

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Laparoscopic Technology of Zhejiang Province Department of General Surgery Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou 310016 China

College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China

State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Hangzhou 310058 China

Institution of Gastroenterology Zhejiang University Hangzhou 310058 China

Department of Pathology of Sir Run Run Shaw Hospital Center of Cryo‐Electron Microscopy Zhejiang University School of Medicine Hangzhou 310058 China

Zhejiang Laboratory of Systems and Precision Medicine Zhejiang University Medical Center Hangzhou 311121 China

MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

Funding

National Natural Science Foundation of China · China Postdoctoral Science Foundation

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