Glucose‐Responsive Insulin and Delivery Systems: Innovation and Translation
Source abstract
Abstract
Abstract Type 1 and advanced type 2 diabetes treatment involves daily injections or continuous infusion of exogenous insulin aimed at regulating blood glucose levels in the normoglycemic range. However, current options for insulin therapy are limited by the risk of hypoglycemia and are associated with suboptimal glycemic control outcomes. Therefore, a range of glucose‐responsive components that can undergo changes in conformation or show alterations in intermolecular binding capability in response to glucose stimulation has been studied for ultimate integration into closed‐loop insulin delivery or “smart insulin” systems. Here, an overview of the evolution and recent progress in the development of molecular approaches for glucose‐responsive insulin delivery systems, a rapidly growing subfield of precision medicine, is presented. Three central glucose‐responsive moieties, including glucose oxidase, phenylboronic acid, and glucose‐binding molecules are examined in detail. Future opportunities and challenges regarding translation are also discussed.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Pancreatic function and diabetes · Diabetes Management and Research · Enzyme Catalysis and Immobilization
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Bioengineering University of California Los Angeles CA 90095 USA
California NanoSystems Institute University of California Los Angeles CA 90095 USA
Zenomics Inc. Durham NC 27709 USA
Department of Medicine University of North Carolina School of Medicine Chapel Hill NC 27599 USA
Jonsson Comprehensive Cancer Center University of California Los Angeles CA 90095 USA
Center for Minimally Invasive Therapeutics University of California Los Angeles CA 90095 USA
Funding
National Institutes of Health · Juvenile Diabetes Research Foundation United States of America · National Science Foundation · American Diabetes Association
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