journal article·2013-04-24

Specific Capture and Release of Circulating Tumor Cells Using Aptamer‐Modified Nanosubstrates

Qinglin Shen, Li Xu, Libo Zhao, Dongxia Wu, Yunshan Fan, Yiliang Zhou, Wei‐Han OuYang, Xiaochun Xu, Zhen Zhang, Min Song, Tom Lee, Mitch A. Garcia, Bin Xiong, Shuang Hou, Hsian‐Rong Tseng, Xiaohong Fang

Advanced Materials· Volume 25· Issue 16
Publisher page

Abstract

A platform for capture and release of circulating tumor cells (CTCs) is demonstrated by utilizing aptamer grafted silicon nanowires. Here, single-stranded DNA-aptamers are generated via the Cell-SELEX process to serve as capture agents, allowing specific capture and release of non-small cell lung cancer (NSCLC) CTCs from whole-blood samples with minimum contamination and negligible disruption to CTC viability and functions.
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Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · RNA Interference and Gene Delivery · Microfluidic and Bio-sensing Technologies

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