A new dual-functional chemsensor for the trace detection of mercury ion and imaging of hypochloric acid
Source abstract
Abstract
Abstract Herein, a new dual-functional chemsensor 2-amino-3-(((E)-(5-(9-phenyl-9H-carbazol-3-yl)thiophen-2-yl)methylene)amino)maleonitrile (abbreviated as FDW) was designed and prepared for the trace detection mercury ion and imaging of hypochloric acid by two different fluorescence channels. The yellow-green channel of FDW was turned on within 6 min after adding trace-level Hg2+ under 365 nm UV lamp irradiation. For the first time, we proved that the chelation of mercury ions with FDW weakened the binding ability of C N, making it easy to break down under UV irradiation and generate the strong fluorescent chromophores. The detection limit was calculated to be as low as 0.34 nM, which demonstrated its potential applications in actual food samples. Interestingly, upon the addition of ClO−, the blue emission of FDW was significantly increased along with color change (from pale yellow to colorless). Under optimal conditions, the calibration curve is linear in the wide concentration range (0–240 μM), and the detection limit was 107 nM. In addition, FDW was successfully used for fluorescence imaging of ClO− in RAW 246.7 cells.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Molecular Sensors and Ion Detection · Advanced biosensing and bioanalysis techniques · Luminescence and Fluorescent Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (54)
Show source-provided references
1. Fluorescent probe for mercury ion imaging analysis: strategies and applications10.1016/j.cej.2020.127166 ↗
2. Trends in sensor development toward next-generation point-of-care testing for mercury10.1016/j.bios.2021.113228 ↗
3. Establishment of a new molecular model for mercury determination verified by single crystal X-ray diffraction, spectroscopic analysis and biological potentials10.1016/j.cclet.2020.09.021 ↗
4. A two-photon fluorescent probe for colorimetric and ratiometric monitoring of mercury in live cells and tissues10.1039/C8CC08608G ↗
5. A novel ratiometric fluorescent probe for selective detection of Hg2+, Cr3+ and Al3+ and its bioimaging application in living cells10.1016/j.snb.2017.07.025 ↗
6. Fluorescent detection of methyl mercury in aqueous solution and live cells using fluorescent probe and micelle systems10.1021/acs.analchem.9b05025 ↗
7. A hydrogel microsphere-based sensor for dual and highly selective detection of Al3+ and Hg2+10.1016/j.snb.2020.128490 ↗
8. Reaction-based fluorescent probes for Hg2+. Cu2+ and Fe3+/Fe2+10.1016/j.ccr.2020.213580 ↗
9. Small molecular fluorescent probes for the detection of lead, cadmium and mercury ions10.1016/j.ccr.2020.213691 ↗
10. Metal-coordinated fluorescent and luminescent probes for reactive oxygen species (ROS) and reactive nitrogen species (RNS)10.1016/j.ccr.2020.213581 ↗
11. A two-photon ESIPT based fluorescence probe for specific detection of hypochlorite10.1016/j.dyepig.2018.01.027 ↗
12. A two-photon fluorescent probe for turn-on monitoring HOCl level in endoplasmic reticulum10.1016/j.dyepig.2020.108435 ↗
13. A ratiometric fluorescent probe for hypochlorous acid and its biological applications10.1016/j.dyepig.2018.07.001 ↗
14. Real-time tracking and dual-mode imaging of hypochlorous acid in vivo by a small-sized fluorescence probe10.1016/j.dyepig.2021.109219 ↗
15. A highly specific fluorescent probe for hypochlorous acid and its application in imaging microbe-induced HOCl production10.1021/ja404649m ↗
16. Reaction-based fluorescent probes for the detection and imaging of reactive oxygen, nitrogen, and sulfur species10.1021/acs.accounts.9b00302 ↗
17. A reaction-based colorimetric and ratiometric chemosensor for imaging identification of HClO in live cells, mung bean sprouts, and paper strips10.1016/j.talanta.2021.122655 ↗
18. Self-assembly of a dual-targeting and self-calibrating ratiometric polymer nanoprobe for accurate hypochlorous acid imaging10.1021/acsami.0c13857 ↗
19. Design principles, sensing mechanisms, and applications of highly specific fluorescent probes for HOCl/OCl-10.1021/acs.accounts.9b00307 ↗
20. Molecular engineering of ultra-sensitive fluorescent probe with large Stokes shift for imaging of basal HOCl in tumor cells and tissues10.1016/j.cclet.2020.08.016 ↗
21. Development of a concise rhodamine-formylhydrazine type fluorescent probe for highly specific and ultrasensitive tracing of basal HOCl in live cells and zebrafish10.1021/acssensors.9b01001 ↗
22. Revealing HOCl burst from endoplasmic reticulum in cisplatin-treated cells via a ratiometric fluorescent probe10.1016/j.cclet.2020.12.039 ↗
23. A novel dual-response chemosensor for bioimaging of exogenous/endogenous hypochlorite and hydrazine in living cells, pseudomonas aeruginosa and zebrafish10.1016/j.snb.2020.128450 ↗
24. Single-dye-doped fluorescent nanoprobe enables self-referenced ratiometric imaging of hypochlorous acid in lysosomes10.1016/j.snb.2019.127299 ↗
25. Ratiometric detection and imaging of endogenous hypochlorite in live cells and in vivo achieved by using an aggregation induced emission (AIE)-based nanoprobe10.1039/C6CC03415B ↗
26. Molecular design toward heavy-atom-free photosensitizers based on the C═S bond and their dual functions in hypoxia photodynamic cancer therapy and ClO- detection10.1021/acsami.0c22174 ↗
27. pH-Response quantum dots with orange-red emission for monitoring the residue, distribution, and variation of an organophosphorus pesticide in an agricultural crop10.1021/acs.jafc.0c08212 ↗
28. Fluorescent probes for the visualization of cell viability10.1021/acs.accounts.9b00289 ↗
29. Equipment-free and visual detection of multiple biomarkers via an aggregation induced emission luminogen-based paper biosensor10.1016/j.bios.2020.112336 ↗
30. Ultrafast size expansion and turn-on luminescence of atomically precise silver clusters by hydrogen sulfide10.1002/anie.202100006 ↗
31. Recent progress in all-visible-light-triggered diarylethenes10.1016/j.dyepig.2020.108623 ↗
32. A novel N-nitrosation-based ratiometric fluorescent probe for highly selective imaging endogenous nitric oxide in living cells and zebrafish10.1016/j.snb.2020.129147 ↗
33. A new fluoride luminescence quencher based on a nanostructured covalently bonded terbium hybrid material10.1021/jp105035v ↗
34. Reversible terbium luminescent polyelectrolyte hydrogels for detection of H2PO4- and HSO4- in water10.1021/ic102366v ↗
35. In situ imaging of cysteine in the brains of mice with epilepsy by a near-infrared emissive fluorescent probe10.1021/acs.analchem.9b05211 ↗
36. A dual-response fluorescent probe for the detection of viscosity and H2S and its application in studying their cross-talk influence in mitochondria10.1021/acs.analchem.8b02068 ↗
37. Activating layered metal oxide nanomaterials via structural engineering as biodegradable nanoagents for photothermal cancer therapy10.1002/smll.202007486 ↗
38. Crafting CdTe/CdS QDs surface for the selective recognition of formaldehyde gas via ratiometric contrivance10.1016/j.snb.2019.127379 ↗
39. Rearrangement regulated cysteine fluorescent probe for cellular oxidative stress evaluation induced by copper(II)10.1016/j.cclet.2020.07.001 ↗
40. General synthesis of ordered mesoporous carbonaceous hybrid nanostructures with molecularly dispersed polyoxometallates10.1002/anie.202104028 ↗
41. Novel difluoroboron complexes of curcumin analogues as “dual-dual” sensing materials for volatile acid and amine vapors10.1016/j.dyepig.2020.108406 ↗
42. Step-wise functionalization of polysiloxane towards a versatile dual-response fluorescent probe and elastomer for the detection of H2S in two-photon and NO in near-infrared modes10.1039/C9CC08723K ↗
43. Rational design of a bifunctional fluorescent probe for distinguishing Hcy/Cys from GSH with ideal properties10.1016/j.cclet.2020.09.024 ↗
44. Reversible chemosensor for bioimaging and biosensing of Zn(II) and hpH in cells, larval zebrafish, and plants with dual-channel fluorescence signals10.1021/acs.inorgchem.0c03456 ↗
45. Evaluating visually a new apoptosis-induced reagent by a ratiometric two-photon fluorescent pH probe10.1016/j.snb.2020.129104 ↗
46. A conformational transition based fluorescent probe for mapping lysosomal viscosity fluctuations by fluorescence lifetime imaging10.1016/j.snb.2020.129432 ↗
47. A dual-site modulated FRET-based two-photon ratiometric fluorescent probe for tracking lysosomal pH changes in living cells, tissues and zebrafish10.1016/j.snb.2019.03.122 ↗
48. Dual-site fluorescent probe to monitor intracellular nitroxyl and GSH-GSSG oscillations10.1021/acs.analchem.8b05098 ↗
49. A new AIEE-active carbazole based colorimetric/fluorimetric chemosensor for ultra-rapid and nano-level determination of Hg2+ and Al3+ in food/environmental samples and living cells10.1016/j.snb.2020.129418 ↗
50. Metallic 1T phase enabling MoS2 nanodots as an efficient agent for photoacoustic imaging guided photothermal therapy in the near-infrared-II window10.1002/smll.202004173 ↗
51. Building rhodamine-BODIPY fluorescent platform using click reaction: naked-eye visible and multi-channel chemodosimeter for detection of Fe3+ and Hg2+10.1016/j.snb.2017.12.146 ↗
52. Chemical sensing failed by aggregation-caused quenching? A case study enables liquid/solid two-phase determination of N2H410.1016/j.cej.2021.128975 ↗
53. Ratiometric-enhanced g-quadruplex probes for amplified and mix-to-read detection of mercury pollution in aquatic products10.1021/acs.jafc.0c05658 ↗
54. A novel ratiometric fluorescent probe based on thienocoumarin and its application for the selective detection of hypochlorite in real water samples and in vivo10.1039/D0NJ00318B ↗