Near-infrared dual-functional AIEgens for lipid droplets imaging in multispecies and photodynamic therapy
Source abstract
Abstract
Abstract Lipid droplets (LDs) are important organelles with hydrophobic structure that not only served the function of lipid storage in cells but also participate in the regulation of numerous metabolic processes. Broad visualization of LDs with high brightness is important for biological applications. In this study, three novel facile near-infrared aggregation-induced emission (AIE) fluorescent bioprobes based on triphenylamine-pyridine building block were designed and synthesized. These AIEgens block exhibits tunable D-D-π-A (D: donor, A: acceptor) structure with twisted intramolecular charge transfer (TICT) characteristics. These bioprobes can highly light up LDs in the living cells, model animal zebrafish and shelled sunflower seed. More importantly, these probes can effectively produce reactive oxygen species (ROS) in the presence of light irradiation, leading to the apoptosis of cancer cells. This study exhibits promising applications in photodynamic therapy through targeting LDs.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Lipid metabolism and biosynthesis · Mass Spectrometry Techniques and Applications · Luminescence and Fluorescent Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (39)
Show source-provided references
1. Lipidomics reveals that adiposomes store ether lipids and mediate phospholipid traffic10.1194/jlr.M600413-JLR200 ↗
2. The life of lipid droplets10.1016/j.bbalip.2008.10.009 ↗
3. Lipid droplets: a unified view of a dynamic organelle10.1038/nrm1912 ↗
4. Lipid droplets as dynamic organelles connecting storage and efflux of lipids10.1016/j.bbalip.2008.08.001 ↗
5. Integrating mechanisms for insulin resistance: common threads and missing links10.1016/j.cell.2012.02.017 ↗
6. Great balls of fat10.1126/science.311.5765.1232 ↗
7. Cellular metabolism and disease: what do metabolic outliers teach us?10.1016/j.cell.2012.02.032 ↗
8. Lipid droplets in inflammation and cancer10.1016/j.plefa.2010.02.005 ↗
9. The size of cytoplasmic lipid droplets varies between tumour cell lines of the nervous system: a 1H NMR spectroscopy study10.1007/s10334-012-0315-x ↗
10. Quantification of lipid metabolism in living cells through the dynamics of lipid droplets measured by stimulated Raman scattering imaging10.1021/acs.analchem.6b04699 ↗
11. The ER-localized protein DFCP1 modulates ER-lipid droplet contact formation10.1016/j.celrep.2019.03.025 ↗
12. NIR dyes for bioimaging applications10.1016/j.cbpa.2009.10.022 ↗
13. Luminescent chemodosimeters for bioimaging10.1021/cr2004103 ↗
14. BODIPY 493/503 staining of neutral lipid droplets for microscopy and quantification by flow cytometry10.21769/BioProtoc.1912 ↗
15. Nile red: a selective fluorescent stain for intracellular lipid droplets10.1083/jcb.100.3.965 ↗
16. Live cell multicolor imaging of lipid droplets with a new dye, LD54010.1111/j.1600-0854.2009.00980.x ↗
17. A pitfall in using BODIPY dyes to label lipid droplets for fluorescence microscopy10.1007/s00418-010-0678-x ↗
18. Aggregation-induced emission of 1-methyl-1,2,3,4,5-pentaphenylsilole10.1039/b105159h ↗
19. Aggregation-induced emission: a trailblazing journey to the field of biomedicine10.1021/acsabm.8b00600 ↗
20. Targeted and image-guided photodynamic cancer therapy based on organic nanoparticles with aggregation-induced emission characteristics10.1039/C4CC02767A ↗
21. Near-infrared fluorescence: application to in vivo molecular imaging10.1016/j.cbpa.2009.09.029 ↗
22. Far-red to near infrared analyte-responsive fluorescent probes based on organic fluorophore platforms for fluorescence imaging10.1039/C2CS35313J ↗
23. Synthetic principles for bandgap control in linear π-conjugated systems10.1021/cr950257t ↗
24. Highly efficient far red/near-Infrared fluorophores with aggregation-induced emission for bioimaging10.1016/j.dyepig.2017.04.004 ↗
25. Facile synthesis of red/NIR AIE luminogens with simple structures, bright emissions, and high photostabilities, and their applications for specific imaging of lipid droplets and image-guided photodynamic therapy10.1002/adfm.201704039 ↗
26. Bright near-infrared aggregation-induced emission luminogens with strong two-photon absorption, excellent organelle specificity, and efficient photodynamic therapy potential10.1021/acsnano.8b03138 ↗
27. Tuning the singlet-triplet energy gap: a unique approach to efficient photosensitizers with aggregation-induced emission (AIE) characteristics10.1039/C5SC01733E ↗
28. A highly efficient and photostable photosensitizer with near-infrared aggregation-induced emission for image-guided photodynamic anticancer therapy10.1002/adma.201700548 ↗
29. Dipolar organic pyridyl dyes for dye-sensitized solar cell applications10.1016/j.tet.2011.10.038 ↗
30. Ferrocene based chemosensor for Cu2+-a dual channel signaling system10.1016/j.talanta.2011.05.026 ↗
31. PLK1-targeted fluorescent tumor imaging with high signal-background-ratio10.1021/acssensors.7b00544 ↗
32. ESIPT-active multi-color aggregation-induced emission features of triphenylamine-salicylaldehyde-based unsymmetrical azine family10.1039/C9CE01490J ↗
33. Structural changes accompanying intramolecular electron transfer: focus on twisted intramolecular charge-transfer states and structures10.1021/cr940745l ↗
34. Mitochondrion-specific live-cell bioprobe operated in a fluorescence turn-on manner and a well-designed photoactivatable mechanism10.1002/adma.201503751 ↗
35. The importance of vibronic coupling for efficient reverse intersystem crossing in thermally activated delayed fluorescence molecules10.1002/cphc.201600662 ↗
36. Photosensitizers with aggregation-induced emission: materials and biomedical applications10.1002/adma.201801350 ↗
37. Highly efficient far red/near-infrared solid fluorophores: aggregation-induced emission, intramolecular charge transfer, twisted molecular conformation, and bioimaging applications10.1002/anie.201507031 ↗
38. Predicting small molecule fluorescent probe localization in living cells using QSAR modeling.2. specifying probe, protocol and cell factors; selecting QSAR models; predicting entry and localization10.3109/10520295.2013.780635 ↗
39. Host-biomaterial interactions in zebrafish10.1021/acsbiomaterials.6b00760 ↗