journal article·2025-12Open access

Reconfigurable Microenvironments Uncover Mechano‐Sensing Timescales and Direct Cell Polarity (Adv. Funct. Mater. 49/2025)

Syuan‐Ku Hsiao, Markus Mukenhirn, Carsten Werner, Alf Honigmann, Elisha Krieg

Advanced Functional Materials· Volume 35· Issue 49

Abstract

Programmable Nanomaterials This cover illustrates the internal architecture of a DNA-crosslinked cell-culture matrix (DyNAtrix). Dynamically switchable DNA crosslinks regulate mechanical interactions between living cells and their three-dimensional microenvironment. Leveraging DNA nanotechnology, DyNAtrix allows researchers to study cellular mechanotransduction and to actively guide the development of cells and organoids in a Petri dish (Design contribution: Yu-Hsuan Peng). More information can be found in the Research Article by Elisha Krieg and co-workers (10.1002/adfm.202513028).
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Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Micro and Nano Robotics · Nanotechnology research and applications

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Affiliations

Division Polymer Biomaterials Science Leibniz Institute of Polymer Research Dresden 01069 Dresden Germany

Center for Regenerative Therapies Dresden Cluster of Excellence Physics of Life and Faculty of Chemistry and Food Chemistry Technische Universität Dresden 01307 Dresden Germany

Biotechnology Center Technische Universität Dresden 01307 Dresden Germany

References

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