Cold Quad‐Modal Nanocomplex for Precise and Quantitative In Vivo Stem Cell Tracking
Source abstract
Abstract
Abstract Current single imaging modalities typically lack the ability to simultaneously offer detailed anatomical visualization and quantitative cellular information, which is crucial for evaluating and improving therapeutic efficacy. This work develops a cold (non‐radioactive) quad‐modal imaging nanocomplex for magnetic resonance imaging (MRI), magnetic particle imaging (MPI), computed tomography (CT), and multispectral optoacoustic tomography (MSOT) within a single nanoplatform, that is, Albumin‐Bismuth‐Superparamagnetic iron oxide or ABS. The chemically engineered complex is composed of bovine serum albumin as biocompatible matrix, superparamagnetic iron oxide as MRI and MPI agents, and optoradiopaque bismuth sulfide as CT and MSOT agents. This work demonstrates here its first use for high‐resolution, real‐time, and quantitative in vivo imaging of mesenchymal stem cells transplanted in mouse brain. This versatile nanocomplex may find applications for non‐invasive monitoring cell transfer and cell transplantation in vivo using multiple imaging approaches.
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Research context
OpenAlex topics: Photoacoustic and Ultrasonic Imaging · Characterization and Applications of Magnetic Nanoparticles · Gold and Silver Nanoparticles Synthesis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
The Russell H. Morgan Department of Radiology and Radiological Science Division of MR Research The Johns Hopkins University School of Medicine Baltimore MD 21205 USA
Cellular Imaging Section and Vascular Biology Program Institute for Cell Engineering The Johns Hopkins University School of Medicine Baltimore MD 21205 USA
The Russell H Morgan Department of Radiology and Radiological Science Division of Cancer Imaging Research The Johns Hopkins University School of Medicine Baltimore MD 21205 USA
Department of Biomedical Engineering The Johns Hopkins University School of Medicine Baltimore MD 21205 USA
Department of Oncology The Johns Hopkins University School of Medicine Baltimore MD 21287 USA
Department of Chemical & Biomolecular Engineering The Johns Hopkins University Whiting School of Engineering Baltimore MD 21218 USA
Funding
National Institutes of Health · Maryland Stem Cell Research Fund · National Cancer Institute
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