DataVXAdvanced Functional MaterialsPaper
journal article·2025-10Open access

Noninvasive Assessment of Protease Activity in Osteosarcoma via Click Chemistry‐Mediated Enrichment of Extracellular Vesicles (Adv. Funct. Mater. 41/2025)

You‐Ren Ji, Junseok Lee, Hyoyong Kim, Hui Kong, Chen Zhao, Yong Ju, Ryan Zhang, Jina Kim, Audrey Qian, Diego Sergio Banuet Gonzalez, Yusef Mathkour, Kenny Vo, Hadar Keren‐Gill, Aaron Phung, Jia‐Wei She, Hsiao‐hua Yu, Sungyong You, Hans David Ulmert, Alice Soragni, Sarah Dry, Joseph Garfield Crompton, Noah Federman, Steven John Jonas, Shaohua Lu, Yazhen Zhu, Hsian‐Rong Tseng

Advanced Functional Materials· Volume 35· Issue 41
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Source abstract

Abstract

Liquid Biopsy In their Research Article (10.1002/adfm.202422469), Junseok Lee, Steven John Jonas, Shaohua Lu, Yazhen Zhu, Hsian-Rong Tseng, and co-workers present a novel osteosarcoma extracellular vesicle matrix metalloproteinase activity assay (OS EV MMP activity assay) for noninvasive and real-time monitoring of disease progression and treatment response in pediatric osteosarcoma. By combining click chemistry-enabled tumor EV enrichment with FRET-based protease activity profiling, the assay quantitatively evaluates six specific EV surface marker/MMP combinations. This minimally invasive platform enables early detection of metastasis and longitudinal disease monitoring, offering a powerful tool to improve clinical management of osteosarcoma.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: RNA Interference and Gene Delivery · Extracellular vesicles in disease · Nanoplatforms for cancer theranostics

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Affiliations

California NanoSystems Institute Crump Institute for Molecular Imaging Department of Molecular and Medical Pharmacology University of California Los Angeles (UCLA) Los Angeles CA 90095 USA

Department of Pathology Zhongshan Hospital Fudan University Shanghai 200032 P. R. China

Department of Pathology and Laboratory Medicine David Geffen School of Medicine at UCLA Los Angeles CA 90095 USA

Departments of Urology and Computational Biomedicine Cedars‐Sinai Medical Center Los Angeles CA 90048 USA

Department of Pediatrics David Geffen School of Medicine Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and Children's Discovery and Innovation Institute UCLA Los Angeles CA 90095 USA

Smart Organic Materials Laboratory Institute of Chemistry Academia Sinica No. 128, Section 2, Academia Road, Nankang Taipei 11529 Taiwan

Department of Molecular and Medical Pharmacology University of California Los Angeles (UCLA) Los Angeles CA 90095 USA

Department of Orthopaedic Surgery David Geffen School of Medicine University of California Los Angeles Los Angeles CA 90095 USA

Division of Surgical Oncology David Geffen School of Medicine Los Angeles CA 90095 USA

References

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