Eco‐Fabricated Nanowave‐Textured Implants Drive Microtubule‐Assisted Nuclear Mechanotransduction and Chromatin Modification: Biophysical Priming for Osteogenesis and Bone Regeneration (Adv. Funct. Mater. 41/2025)

Bosu Jeong; Ji‐Young Yoon; Junyong Ahn; Byunghak Lee; Sung‐Min Park; Jae‐Heon Kim; Buuvee Bayarkhangai; Yu Jin Kim; Sak Lee; Jonathan C. Knowles; Moon‐Young Kim; DongJun Lee; Sang‐Hoon Rhee; Hae‐Hyoung Lee; Hae‐Won Kim; Jung‐Hwan Lee

doi:10.1002/adfm.71855

journal article·2025-10Open access

Eco‐Fabricated Nanowave‐Textured Implants Drive Microtubule‐Assisted Nuclear Mechanotransduction and Chromatin Modification: Biophysical Priming for Osteogenesis and Bone Regeneration (Adv. Funct. Mater. 41/2025)

Bosu Jeong, Ji‐Young Yoon, Junyong Ahn, Byunghak Lee, Sung‐Min Park, Jae‐Heon Kim, Buuvee Bayarkhangai, Yu Jin Kim, Sak Lee, Jonathan C. Knowles, Moon‐Young Kim, DongJun Lee, Sang‐Hoon Rhee, Hae‐Hyoung Lee, Hae‐Won Kim, Jung‐Hwan Lee

Advanced Functional Materials· Volume 35· Issue 41

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Source abstract

Abstract

Eco-Processed Nanowave-Textured Implants In their Research Article (10.1002/adfm.202503422), Sang-Hoon Rhee, Hae-Hyoung Lee, Hae-Won Kim, Jung-Hwan Lee, and co-workers report strong acid-free, eco-fabricated nanowave-textured implants that drive microtubule-assisted nuclear mechanotransduction for enhanced osteogenesis. The green-processed femtosecond laser-fabricated nanowave induces cellular and nuclear alignment along the wave axis and activates mechanosensitive pathways, leading to chromatin modifications that mediate stem cell priming for improved bone regeneration.

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Research context

Nanomaterials Biomaterials

OpenAlex topics: Bone Tissue Engineering Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Dental Biomaterials Science Dental Research Institute School of Dentistry Seoul National University Seoul 03080 Republic of Korea

Surface Science Research Center B2LAB Co. Ltd Seoul 05836 Republic of Korea

Institute of Tissue Regeneration Engineering (ITREN) Dankook University Cheonan Chungcheongnam‐do 31116 Republic of Korea

Department of Nanobiomedical Science and BK21 PLUS NBM Global Research Center for Regenerative Medicine Dankook University Cheonan Chungcheongnam‐do 31116 Republic of Korea

Institute for Stem Cell & Matters Cell & Matter Corporation Cheonan 31116 Republic of Korea

Department of Biomaterials Science College of Dentistry Dankook University Cheonan Chungcheongnam‐do 31116 Republic of Korea

Department of Oral Pathology Seoul National University Dental Hospital Seoul 03080 Republic of Korea

Department of Oral Pathology School of Dentistry Seoul National University Seoul 03080 Republic of Korea

UCL Eastman‐Korea Dental Medicine Innovation Centre Dankook University Cheonan Chungcheongnam‐do 31116 Republic of Korea

Division of Biomaterials and Tissue Engineering UCL Eastman Dental Institute Royal Free Hospital Rowland Hill Street London NW3 2PF UK

Department of Oral and Maxillofacial Surgery College of Dentistry Dankook University Cheonan 31116 Republic of Korea

Department of Oral Histology Dankook University College of Dentistry Cheonan 31116 Republic of Korea

Mechanobiology Dental Medicine Research Center Dankook University Cheonan 31116 Republic of Korea

References

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