DataVXAdvanced Functional MaterialsPaper
journal article·2025-06Open access

Engineered Cell‐Derived Nanovesicles with CAR and PH20 for Enhanced Targeted Photodynamic Cancer Therapy and Tumor Microenvironment Modulation (Adv. Funct. Mater. 25/2025)

Hyeon‐Ji Oh, Gwang Yeol Park, Jieun Han, Boram Son, Jun‐Hyeok Han, Hyomin Choi, Chun Gwon Park, Dong Wook Choi, Sung‐Soo Park, Wooram Park, Hee Ho Park

Advanced Functional Materials· Volume 35· Issue 25
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Source abstract

Abstract

Engineered Cell-Derived Nanovesicles In article number 2418138, Wooram Park, Hee Ho Park, and co-workers introduce engineered cell-derived nanovesicles (CNVs) equipped with chimeric antigen receptors (CAR) and PH20 hyaluronidase. These nanovesicles enhance targeted photodynamic therapy (PDT) by improving tumor penetration and modulating the tumor microenvironment. The combined approach demonstrates improved therapeutic efficacy in overcoming tumor-associated barriers, presenting a promising strategy for effective cancer treatment.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics

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Affiliations

Department of Integrative Biotechnology College of Biotechnology and Bioengineering Sungkyunkwan University (SKKU) 2066, Seobu‐ro, Jangan‐gu Suwon Gyeonggi 16419 Republic of Korea

Department of Bioengineering College of Engineering Hanyang University 222, Wangsimni‐ro, Seongdong‐gu Seoul 04763 Republic of Korea

Department of Bio and Fermentation Convergence Technology Kookmin University 77, Jeongneung‐ro, Seongbuk‐gu Seoul 02707 Republic of Korea

Department of Biomedical Engineering, Institute for Cross‐disciplinary Studies (ICS) SKKU 2066, Seobu‐ro, Jangan‐gu Suwon Gyeonggi 16419 Republic of Korea

Department of Biotechnology College of Life Sciences and Biotechnology Korea University 145, Anam‐ro, Seongbuk‐gu Seoul 02841 Republic of Korea

Biodrone Research Institute Mdimune Inc. 49, Achasan‐ro, Seongdong‐gu Seoul 04790 Republic of Korea

Department of MetaBioHealth, ICS SKKU 2066, Seobu‐ro, Jangan‐gu Suwon Gyeonggi 16419 Republic of Korea

Department of Biotechnology, College of Life Sciences and Biotechnology Korea University 145, Anam‐ro, Seongbuk‐gu Seoul 02841 Republic of Korea

SIMPLE Planet Inc. 48, Achasan‐ro 17‐gil, Seongdong‐gu Seoul 04799 Republic of Korea

References

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