DataVXAdvanced Functional MaterialsPaper
journal article·2025-05Open access

Amplification‐Free, Sequencing‐Free, Detection of Viral RNAs with Variant Specification by Discrete Nanocounting (Adv. Funct. Mater. 21/2025)

Zixun Wang, Xi Zhao, Wan‐Mui Chan, Xianglin Ji, Linfeng Huang, Xi Xie, Wei Li, Wenjun Zhang, Kelvin Kai‐Wang To, Peng Shi

Advanced Functional Materials· Volume 35· Issue 21
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Source abstract

Abstract

NanoPick Array In article number 2310157, Kelvin Kai-Wang To, Peng Shi, and co-workers develop a biochip with vertically aligned nanostructures, NanoPick-array, for rapid analysis of viral RNAs. The platform combines selective short-cut of viral RNAs, cherry-picking isolation of target genes, and micro-arrayed discrete nanoimaging to enable the detection of COVID-19 RNAs without the need for amplification and sequencing, providing the capability to differentiate single-nucleotide genetic mutation among different viral variants.
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Research context

Nanomaterials

OpenAlex topics: Integrated Circuits and Semiconductor Failure Analysis · Advanced biosensing and bioanalysis techniques

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Affiliations

Department of Biomedical Engineering City University of Hong Kong Kowloon Hong Kong SAR 999077 China

CAS Key Laboratory of Nano‐Bio Interface Suzhou Institute of Nano‐Tech and Nano‐Bionics Chinese Academy of Sciences Suzhou 215123 China

Hong Kong Centre for Cerebro‐Cardiovascular Health Engineering Hong Kong Science Park Hong Kong SAR 999077 China

State Key Laboratory for Emerging Infectious Diseases Carol Yu Centre for Infection Department of Microbiology School of Clinical Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong SAR 999077 China

Division of Natural and Applied Sciences Duke Kunshan University Kunshan 215316 China

State Key Laboratory of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information Technology Sun Yat‐Sen University Guangzhou 510006 China

School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China

Department of Materials Science and Engineering City University of Hong Kong Kowloon Hong Kong SAR 999077 China

Center of Super‐Diamond and Advanced Films (COSDAF) City University of Hong Kong Kowloon Hong Kong SAR 999077 China

Shenzhen Research Institute City University of Hong Kong Shenzhen 518000 China

Centre for Virology Vaccinology and Therapeutics Hong Kong Science and Technology Park Hong Kong SAR 999077 China

Department of Microbiology Queen Mary Hospital Pokfulam Hong Kong SAR 999077 China

Department of Infectious Disease and Microbiology The University of Hong Kong‐Shenzhen Hospital Shenzhen 518000 China

References

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