journal article·2025-04Open access

Robust Systemic and Mucosal Immune Responses to Coxsackievirus B3 Elicited by Spider Silk Protein Based Nanovaccines via Subcutaneous Immunization (Adv. Funct. Mater. 15/2025)

Xingmei Qi, Guoqiang Wei, Yanan Li, Sidong Xiong, Gefei Chen

Advanced Functional Materials· Volume 35· Issue 15

Abstract

Spider Silk Protein-Based Nanovaccines In article number 2407568, Xingmei Qi, Sidong Xiong, Gefei Chen, and co-workers show that spider silk protein-based nanovaccines are capable of eliciting both mucosal and systemic immune responses following subcutaneous administration and demonstrate significant protective effects against Coxsackievirus B3 infection, offering a promising approach in peptide-based parenteral vaccine strategies.
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Research context

OpenAlex topics: Silk-based biomaterials and applications · Viral Infections and Immunology Research · Viral Infectious Diseases and Gene Expression in Insects

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Affiliations

The Jiangsu Key Laboratory of Infection and Immunity Institutes of Biology and Medical Sciences Soochow University Suzhou 215123 China

Department of Neurosurgery Changhai Hospital Naval Medical University Shanghai 200433 China

Department of Biosciences and Nutrition Karolinska Institutet Huddinge 14157 Sweden

Department of Cell and Molecular Biology Uppsala University Uppsala 75105 Sweden

References

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