Engineered Nanotopographies Induce Transient Openings in the Nuclear Membrane (Adv. Funct. Mater. 6/2025)
Source abstract
Abstract
Engineered Nanotopographies In article number 2410035, Zeinab Jahed and co-workers show that engineered nanotopographies create transient openings in the nuclear membrane without direct penetration into the cell. The study reveals how these membrane disruptions, caused by nanoscale curvature, are naturally repaired via ESCRT-mediated mechanisms. These findings offer new opportunities in biomedical technology and targeted therapies by allowing manipulation of the nuclear membrane, with potential applications in nuclear-targeted delivery and intracellular sensing. Art by the team of INMYWORK Studio.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Force Microscopy Techniques and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Aiiso Yufeng Li Family Department of Chemical and Nano Engineering University of California San Diego La Jolla San Diego CA 92093 USA
Shu Chien‐Gene Lay Department of Bioengineering University of California San Diego La Jolla San Diego CA 92093 USA
Department of Chemistry and Biochemistry University of California San Diego La Jolla San Diego CA 92093 USA
Department of Pharmacology University of California La Jolla San Diego CA 92093 USA
References
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