Chemokine‐Based Injectable Navigation System for Enhancing CAR‐T Cell Therapy Against Solid Tumors (Adv. Funct. Mater. 36/2024)
Source abstract
Abstract
CAR-T Cell Therapy In article number 2401161, Yiran Zheng and co-workers present a chemokine-based Injectable platform for boosting adoptive T cells' efficacy (CITE). The system substantially promotes the tumor-specific migration of injected CAR-T cells and boosts the function of infiltrated T cells, thus improving the efficacies of CAR-T cell therapy to solid tumors. CITE also enhances systemic anti-tumor immunity and elicits immune memory, enabling CITE to treat multimodal and recurrent tumors. CITE is broadly applicable to adoptive cell therapies.
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Research context
OpenAlex topics: CAR-T cell therapy research
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Affiliations
College of Pharmaceutical Sciences Soochow University 199 Ren Ai Road, Suzhou Industrial Park Suzhou 215123 P. R. China
Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development Soochow University Suzhou 215123 P. R. China
Suzhou International Joint Laboratory for Diagnosis and Treatment of Brain Diseases Soochow University Suzhou 215123 P. R. China
References
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