DataVXAdvanced Functional MaterialsPaper
journal article·2024-08Open access

Multi‐Scale Ice Inhibition Platform Enables Full‐Cycle Cryogenic Protection for Mouse Oocyte (Adv. Funct. Mater. 33/2024)

Tie Chang, Conghui Tian, Yifan Zheng, Yating Yang, Tao Liu, Zhongrong Chen, Yue Shao, Qinghua Shi, Huanzhong Liu, Yunxia Cao, Gang Zhao

Advanced Functional Materials· Volume 34· Issue 33
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Source abstract

Abstract

Full-Cycle Cryogenic Protection In article number 2402312, Huanzhong Liu, Yunxia Cao, Gang Zhao, and co-workers propose a multi-scale ice inhibition platform, which effectively suppresses ice crystal morphology, ice recrystallization, thermal stress, and devitrification. Based on this ice inhibition platform, they achieve high-efficiency cryopreservation of mouse oocyte using the low concentration of penetrating cryoprotective agents. Meanwhile, recovered oocytes retain normal fertilization, embryonic development, and birth to healthy offspring, offering promising prospects for achieving high-quality fertility preservation.
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Research context

OpenAlex topics: nanoparticles nucleation surface interactions · Tissue Engineering and Regenerative Medicine

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Affiliations

Department of Electronic Engineering and Information Science University of Science and Technology of China Hefei 230027 China

Institute of Biomechanics and Medical Engineering Department of Engineering Mechanics School of Aerospace Engineering Tsinghua University Beijing 100084 China

Department of Psychiatry Chaohu Hospital of Anhui Medical University Hefei 230032 China

Division of Reproduction and Genetics First Affiliated Hospital of USTC Hefei National Laboratory for Physical Science at Microscale the CAS Key Laboratory of Innate Immunity and Chronic Disease School of Basic Medical Sciences Division of Life Sciences and Medicine Biomedical Sciences and Health Laboratory of Anhui Province CAS Center for Excellence in Molecular Cell Scienc Collaborative Innovation Center of Genetics and Development University of Science and Technology of China Hefei 230027 China

School of Biomedical Engineering Anhui Medical University Hefei 230032 China

Reproductive Medicine Center Department of Obstetrics and Gynecology the First Affiliated Hospital of Anhui Medical University Hefei 230032 China

NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract (Anhui Medical University) Hefei 230032 China

Engineering Research Center of Biopreservation and Artificial Organs Ministry of Education Hefei 230032 China

References

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