DataVXAdvanced Functional MaterialsPaper
journal article·2024-03Open access

Selenoprotein‐Regulated Hydrogel for Ultrasound‐Controlled Microenvironment Remodeling to Promote Bone Defect Repair (Adv. Funct. Mater. 12/2024)

Renhao Xu, Yuanyuan You, Wenyi Zheng, Li Ma, Yanzhou Chang, Shuya Pan, Yanni He, Meijun Zhou, Zhili Xu, Tianfeng Chen, Hongmei Liu

Advanced Functional Materials· Volume 34· Issue 12
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Source abstract

Abstract

Selenoprotein-Regulated Hydrogels In article number 2313122, Hongmei Liu, Tianfeng Chen, and co-workers report an innovative ultrasound-modulatable hydrogel platform with selenoprotein-mediated antioxidant effects to promote bone injury repair. This hydrogel platform encapsulates oxygen-enriched selene-incorporated thin-shell silicon within methacrylate gelatin, then releases selenocystine and oxygen under US control, remodeling the microenvironment of hypoxia and high ROS in bone defects. It shows promising potential for the fostering bone regeneration.
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Research context

Polymers

OpenAlex topics: Laser Applications in Dentistry and Medicine · Medical and Biological Ozone Research · Selenium in Biological Systems

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Affiliations

The Second School of Clinical Medicine Southern Medical University Guangzhou 510515 China

Department of Ultrasound Institute of Ultrasound in Musculoskeletal Sports Medicine The Affiliated Guangdong Second Provincial General Hospital of Jinan University Guangzhou 510317 China

MOE Key Laboratory of Tumor Molecular Biology Department of Chemistry Jinan University Guangzhou 510632 China

Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Hangzhou Normal University Hangzhou 311121 China

References

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