DataVXAdvanced Functional MaterialsPaper
journal article·2023-08Open access

Macrophage Hitchhiking Nanoparticles for the Treatment of Myocardial Infarction: An In Vitro and In Vivo Study (Adv. Funct. Mater. 34/2023)

Giulia Torrieri, Imran Iqbal, Flavia Fontana, Virpi Talman, Heidi Liljenbäck, Andriana Putri, Wail Nammas, Johan Rajander, Xiang Guo‐Li, Philip S. Low, Tambet Teesalu, Anne Roivainen, Jouni Hirvonen, Heikki Ruskoaho, Vimalkumar Balasubramanian, Antti Saraste, Hélder A. Santos

Advanced Functional Materials· Volume 33· Issue 34
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Source abstract

Abstract

Heart Targeting Nanoparticles In article number 2303658, Hélder A. Santos, Antti Saraste, Vimalkumar Balasubramanian, Giulia Torrieri, and co-workers develop a dual drug-loaded acetalated dextran-based precision nanosystem, that relies on the heart targeting properties of atrial natriuretic peptide (ANP) and lin-TT1 peptide-mediated hitchhiking on M2-like macrophages to target the infarcted heart. These nanoparticles show increased heart targeting at day 7 post-MI compared to particles conjugated only with ANP.
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Research context

Nanomaterials

OpenAlex topics: Tissue Engineering and Regenerative Medicine · Graphene and Nanomaterials Applications · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Drug Research Program Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki FI‐00140 Helsinki Finland

Turku PET Centre University of Turku 20521 Turku Finland

Drug Research Program Division of Pharmacology and Pharmacotherapy Faculty of Pharmacy University of Helsinki FI‐00140 Helsinki Finland

Turku Center for Disease Modeling University of Turku FI‐20014 Turku Finland

Accelerator Laboratory Åbo Akademi University Turku FI‐20500 Finland

InFLAMES Research Flagship Center University of Turku Turku Finland

Department of Chemistry Purdue University West Lafayette IN 47907‐2084 USA

Laboratory of Cancer Biology Institute of Biomedicine and Translational Medicine Centre of Excellence for Translational Medicine University of Tartu Tartu 50411 Estonia

Cancer Research Center Sanford‐Burnham Medical Research Institute La Jolla California 92037 USA

Turku PET Centre Turku University Hospital 20521 Turku Finland

Chemical and Pharmaceutical Development Bayer Oy FI‐20210 Turku Finland

Heart Center Turku University Hospital 20521 Turku Finland

Institute of Clinical Medicine Turku University Hospital 20520 Turku Finland

Department of Biomedical Engineering University Medical Center Groningen University of Groningen A. Deusinglaan 1 9713 AV Groningen The Netherlands

W.J. Kolff Institute for Biomedical Engineering and Materials Science University Medical Center Groningen University of Groningen A. Deusinglaan 1 9713 AV Groningen The Netherlands

References

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