Inosine‐Based Supramolecular Hydrogel for Highly Efficient PD‐L1 Blockade Therapy via Mediating CD8+ T Cells (Adv. Funct. Mater. 33/2022)
Source abstract
Abstract
Tumor Immunotherapeutic Gels In article number 2204273, Dunfang Zhang, Hang Zhao, and co-workers demonstrate that an inosine-based supramolecular hydrogel, IPBisoG, can achieve the gradual and sequential release of inosine and aPDL1. Inosine, which enhancs the proliferation and function of CD8+ T cells, together with aPDL1, the blocker of the immunosuppressive pathway in the tumor microenvironment, could highly enhance the in vivo efficacy of PD-L1 blockade therapy.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Adenosine and Purinergic Signaling · Peptidase Inhibition and Analysis
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Affiliations
State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management Med‐X Center for Materials West China Hospital of Stomatology Sichuan University Chengdu Sichuan 610041 P. R. China
Department of Biotherapy State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University Chengdu Sichuan 610041 P. R. China
References
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