DataVXDigest Journal of Nanomaterials and BiostructuresPaper
journal article·2022-09-25Open access

RGD peptide functionalized graphene oxide: a bioactive surface for cell-material interactions

School of Medicine, Hubei Polytechnic University, Huangshi 435003, China, C. H. Zhao, X. P. Zhang, Division of Academic Research, Tongren Polytechnic College, Tongren 554300, China, L. Zhang, Department of Pharmacy,Changhai Hospital, Naval Medical University, Shanghai 200433, China

Digest Journal of Nanomaterials and Biostructures· Volume 17· Issue 3
Publisher pageOpen full text
Source abstract

Abstract

Recently, functionalized graphene-based nanomaterials have gained tremendous attention in biomedical field owing to their biocompatibility, surface functionalizability and their unique mechanical, electronic, and optical properties. Herein, we report a facile one step modification of graphene oxide by RGD peptide, which is known to improve the tissue– material contact by highly specific binding to cellular membrane receptors known as integrins. A detailed structural and morphological characterization of the obtained RGD functionalized graphene oxide (GO-RGD) was performed. The synthesized bioactive composite was used to prepare RGD-GO films by a vacuum filtration method. Additionally, mouse osteoblastic cell (MC3T3-E1) functions including cell attachment, adhesion, proliferation, and differentiation were investigated on GO-RGD films. The results indicated that MC3T3-E1 cell functions were significantly enhanced on GO-RGD films comparing with GO films without functionalization. This study not only demonstrates a facile approach to functionalize graphene oxide with bioactive peptides, but also provides a potential biomaterial for bone repair by improving osteoblastic cell functions.
Source: crossref · Quality: baseline

Research context

NanomaterialsBiomaterialsComposites

OpenAlex topics: Graphene and Nanomaterials Applications · Supramolecular Self-Assembly in Materials · Bone Tissue Engineering Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References (22)

Show source-provided references
1. [1] Shin, H., Biomaterials, 2007. 28(2): p. 126-133; https://doi.org/10.1016/j.biomaterials.2006.08.00710.1016/j.biomaterials.2006.08.007 ↗
2. [2] Chung, C., et al., Accounts of Chemical Research, 2013. 46(10): p. 2211-2224. https://doi.org/10.1021/ar300159f10.1021/ar300159f ↗
3. [3] Papi, M., Int J Mol Sci, 2021. 22(2); https://doi.org/10.3390/ijms2202067210.3390/ijms22020672 ↗
4. [4] Gaur, M., et al., Nanotubes, Nanofibers, and Graphene. Materials (Basel), 2021. 14(20); https://doi.org/10.3390/ma1420597810.3390/ma14205978 ↗
5. [5] Grant, J.J., et al., ACS Biomater Sci Eng, 2021. 7(4): p. 1278-1301; https://doi.org/10.1021/acsbiomaterials.0c0166310.1021/acsbiomaterials.0c01663 ↗
6. [6] Prattis, I., et al., Trends Biotechnol, 2021. 39(10): p. 1065-1077; https://doi.org/10.1016/j.tibtech.2021.01.00510.1016/j.tibtech.2021.01.005 ↗
7. [7] Sattari, S., et al., Int J Nanomedicine, 2021. 16: p. 5955-5980; https://doi.org/10.2147/IJN.S24971210.2147/IJN.S249712 ↗
8. [8] Donahue, H.J., et al., Biomaterials, 2007. 28(10): p. 1787-179710.1016/j.biomaterials.2006.12.020 ↗
9. [9] Lagunas, A., et al., Nano Research, 2014. 7(3): p. 399-409; https://doi.org/10.1007/s12274-014-0406-210.1007/s12274-014-0406-2 ↗
10. [10] Vigneswari, S., et al., Front Bioeng Biotechnol, 2020. 8: p. 567693; https://doi.org/10.3389/fbioe.2020.56769310.3389/fbioe.2020.567693 ↗
11. [11] Makowski, L., W. Olson-Sidford, and W.W. J, Viruses, 2021. 13(2); https://doi.org/10.3390/v1302014610.3390/v13020146 ↗
12. [12] Hu, X.B., et al., Applied Surface Science, 2015. 329: p. 83-86; https://doi.org/10.1016/j.apsusc.2014.12.11010.1016/j.apsusc.2014.12.110 ↗
13. [13] An, J., et al., Materials Science & Engineering C-Materials for Biological Applications, 2013. 33(5): p. 2827-2837; https://doi.org/10.1016/j.msec.2013.03.00810.1016/j.msec.2013.03.008 ↗
14. [14] Liu, H.Y., et al., Nanoscale, 2014. 6(10): p. 5315-5322; https://doi.org/10.1039/c4nr00355a10.1039/c4nr00355a ↗
15. [15] Lehnfeld, J., et al., J Dent Res, 2021. 100(10): p. 1047-1054; https://doi.org/10.1177/0022034521102227310.1177/00220345211022273 ↗
16. [16] Cordeiro, A.L., et al., Biointerphases, 2019. 14(5): p. 051005; https://doi.org/10.1116/1.512124910.1116/1.5121249 ↗
17. [17] Slack, R.J., et al., Nat Rev Drug Discov, 2022. 21(1): p. 60-78 https://doi.org/10.1038/s41573-021-00284-410.1038/s41573-021-00284-4 ↗
18. [18] Tjong, W.Y. and H.H. Lin, Sci Rep, 2019. 9(1): p. 1517; https://doi.org/10.1038/s41598-018-38045-w10.1038/s41598-018-38045-w ↗
19. [19] Gotoh, Y., K. Hiraiwa, and M. Nagayama, Bone and mineral, 1990. 8(3): p. 239-50; https://doi.org/10.1016/0169-6009(90)90109-S10.1016/0169-6009(90)90109-S ↗
20. [20] Wu, X.H. and S.F. Wang, Acs Applied Materials & Interfaces, 2012. 4(9): p. 4966-4975; https://doi.org/10.1021/am301334s10.1021/am301334s ↗
21. [21] Davidson, P.M., et al., Advanced Materials, 2009. 21(35): p. 3586-+; https://doi.org/10.1002/adma.20090058210.1002/adma.200900582 ↗
22. [22] He, W., et al., Nat Commun, 2020. 11(1): p. 1732; https://doi.org/10.1038/s41467-020-15524-110.1038/s41467-020-15524-1 ↗