DataVXAdvanced Functional MaterialsPaper
journal article·2021-09Open access

Oxygen‐Generating Cryogels Restore T Cell Mediated Cytotoxicity in Hypoxic Tumors (Adv. Funct. Mater. 37/2021)

Thibault Colombani, Loek J. Eggermont, Stephen M. Hatfield, Zachary J. Rogers, Mahboobeh Rezaeeyazdi, Adnan Memic, Michail V. Sitkovsky, Sidi A. Bencherif

Advanced Functional Materials· Volume 31· Issue 37
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Source abstract

Abstract

Oxygen-Generating Cryogels In article number 2102234, Sidi A. Bencherif and co-workers use injectable oxygen-generating cryogels (O2-cryogels) as a strategy to boost antitumor immune responses. These noninvasive biomaterials are designed to controllably release oxygen, reverse hypoxia-driven immunosuppression, and promote the infiltration of pre-existing immune-fighting immune cells into tumors. O2-cryogels are a novel platform to deliver oxygen locally as a coadjuvant, reinforce tumor-infiltrating T cells, and ultimately enhance cancer immunotherapies.
Source: openalex_inverted_index · Quality: baseline

Research context

BiomaterialsComposites

OpenAlex topics: Nanoplatforms for cancer theranostics · Immune cells in cancer · Cancer, Hypoxia, and Metabolism

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical Engineering Northeastern University Boston MA 02115 USA

New England Inflammation and Tissue Protection Institute Northeastern University 360 Huntington Avenue Boston MA 02115 USA

Center of Nanotechnology King Abdulaziz University Jeddah Makkah 21589 Saudi Arabia

Department of Bioengineering Northeastern University Boston MA 02115 USA

Harvard John A. Paulson School of Engineering and Applied Sciences Harvard University Cambridge MA 02138 USA

Biomechanics and Bioengineering (BMBI) UTC CNRS UMR 7338 University of Technology of Compiègne Sorbonne University Compiègne 60203 France

References

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