DataVXAdvanced Functional MaterialsPaper
journal article·2020-12Open access

Sarcoma‐Derived Extracellular Vesicles: Coupling Nanostructured Microchips with Covalent Chemistry Enables Purification of Sarcoma‐Derived Extracellular Vesicles for Downstream Functional Studies (Adv. Funct. Mater. 49/2020)

Jiantong Dong, Ryan Y. Zhang, Na Sun, Junhui Hu, Matthew D. Smalley, Anqi Zhou, Yue Hua, Winston Rothermich, Mengxiang Chen, Jiayuan Chen, Jinglei Ye, Pai‐Chi Teng, Dongping Qi, Jeffrey A. Toretsky, James S. Tomlinson, Mengyuan Li, Paul S. Weiss, Steven J. Jonas, Noah Federman, Lily Wu, Meiping Zhao, Hsian‐Rong Tseng, Yazhen Zhu

Advanced Functional Materials· Volume 30· Issue 49
Publisher pageOpen full text
Source abstract

Abstract

In article number 2003237, Meiping Zhao, Hsian-Rong Tseng, Yazhen Zhu, and co-workers present a device for the purification of Ewing sarcoma-derived extracellular vesicles (EVs) by coupling LINGO-1 antibodies with the covalent chemistry-mediated EV capture/release mechanism using a nanostructure-embedded microchip. The purified EVs can be internalized by recipient cells to transfer the mRNA cargoes, highlighting the role of EVs as biological shuttles in intercellular communication.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

California NanoSystems Institute Crump Institute for Molecular Imaging Department of Molecular and Medical Pharmacology University of California Los Angeles (UCLA) 570 Westwood Plaza Los Angeles CA 90095 USA

Beijing National Laboratory for Molecular Sciences MOE Key Laboratory of Bioorganic Chemistry and Molecular Engineering College of Chemistry and Molecular Engineering Peking University 202 Chengfu Road, Haidian District Beijing 100871 China

Department of Molecular and Medical Pharmacology David Geffen School of Medicine UCLA 650 Charles E Young Dr. Los Angeles CA 90095 USA

Departments of Oncology and Pediatrics Georgetown University 3970 Reservoir Rd NW Washington DC 20057 USA

Department of Surgery UCLA 200 Medical Plaza Los Angeles CA 90024 USA

California NanoSystems Institute Departments of Chemistry and Biochemistry Bioengineering, and Materials Science and Engineering UCLA 570 Westwood Plaza Los Angeles CA 90095 USA

Department of Pediatrics Ronald Reagan UCLA Medical Center UCLA Mattel Children's Hospital 10833 Le Conte Ave Los Angeles CA 90095 USA

References

Reference metadata was not supplied for this record.