DataVXAdvanced Functional MaterialsPaper
journal article·2019-03Open access

Immunotherapy: MAPK‐Targeted Drug Delivered by a pH‐Sensitive MSNP Nanocarrier Synergizes with PD‐1 Blockade in Melanoma without T‐Cell Suppression (Adv. Funct. Mater. 12/2019)

Xiaowei Liu, Yanlin Feng, Guangchao Xu, Yang Chen, Ya Luo, Jinen Song, Yu Bao, Jiqiao Yang, Chune Yu, Yanna Li, Haoyu Ye, Bowen Ke, Bo Chen, Jianping Hu, Jie Xu, Huan Meng, Haiyuan Zhang, Hubing Shi

Advanced Functional Materials· Volume 29· Issue 12
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Source abstract

Abstract

In article number 1806916, Haiyuan Zhang, Hubing Shi, and co-workers provide a novel framework for combining targeted therapy and immune checkpoint blockade by using a mesoporous silica nanoparticle (MSNP) system. The MSNP-carried MEK inhibitor is specifically enriched in the tumor microenvironment, and selectively internalized by tumor cells rather than T-cells. The cellular-specific delivery avoids T-cell toxicity and synergizes oncogene-targeted therapy and PD-1 blockade.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Immune cells in cancer · Cancer Immunotherapy and Biomarkers

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Laboratory of Tumor Targeted and Immune Therapy Clinical Research Center for Breast State Key Laboratory of Biotherapy West China Hospital Sichuan University and Collaborative Innovation Center Chengdu Sichuan 610041 China

Laboratory of Chemical Biology Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun Jilin 130022 China

University of Science and Technology of China Hefei Anhui 230026 China

Laboratory of Anesthesiology and Critical Care Medicine Translational Neuroscience Center, West China Hospital Sichuan University Chengdu Sichuan 610041 China

Conmed Biosciences Inc. Chengdu Sichuan 61004 China

College of Pharmacy and Biological Engineering Chengdu University Chengdu Sichuan 610106 China

MOH Key Laboratory of Gastroenterology and Hepatology State Key Laboratory for Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200240 China

Division of NanoMedicine Department of Medicine University of California Los Angeles CA 90095 USA

References

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