Preparation of DNA Nanotubes Decorated With Gold Nanoparticles Based on DNA Origami
Source abstract
Abstract
The controlled arrangement of metal nanoparticles is crucial for the development of plasmonic devices. Deoxyribonucleic acid (DNA) origami provides a template for nanoparticle assembly. Herein, the caDNAno software was used to design double-layered DNA nanotubes with capture sites for gold nanoparticles (AuNPs). Functionalized AuNPs were conjugated to the nanotubes via sequence-specific probe hybridization. The resulting hybrid nanostructures were characterized using agarose gel electrophoresis, atomic force microscopy, and transmission electron microscopy. AuNPs were found to be periodically arranged along the DNA nanotubes in a helical configuration. Ultraviolet–visible spectroscopy revealed a red shift of the localized surface plasmon resonance peak, which indicated plasmonic coupling between the helically arranged nanoparticles. Our method holds promise for optical sensing and detection.
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Research context
OpenAlex topics: Advanced biosensing and bioanalysis techniques · Gold and Silver Nanoparticles Synthesis and Applications · DNA and Nucleic Acid Chemistry
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Materials Engineering, Jiangsu University of Technology, 213001 Changzhou, Jiangsu, China
School of Mechanical Engineering, Jiangsu University of Technology, 213001 Changzhou, Jiangsu, China
Funding
National Natural Science Foundation of China · Postgraduate Research & Practice Innovation Program of Jiangsu Province · Practice Innovation Program of Jiangsu University of Technology
References (18)
Show source-provided references
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