journal article·2016-09Open access

Bioinspired Microenvironments: Material‐Driven Fibronectin Assembly Promotes Maintenance of Mesenchymal Stem Cell Phenotypes (Adv. Funct. Mater. 36/2016)

Patricia Rico, Hayk Mnatsakanyan, Matthew J. Dalby, Manuel Salmerón‐Sánchez

Advanced Functional Materials· Volume 26· Issue 36

Abstract

P. Rico, M. Salmerón-Sánchez, and co-workers present an engineered material-driven fibronectin (FN) interface on page 6563. Poly(ethyl acrylate) induces spontaneous organization of FN into nanonetworks mimicking natural FN observed in biological stem cell niches. By promoting maintenance of stemness under basal conditions (undifferentiated stem cells shown in the picture), and by enhancing cell differentiation under defined media this material provides wide versatility for stem cell research and biomedical applications.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications

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Affiliations

Biomedical Research Networking Center in Bioengineering, Biomaterials and Nanomedicine (CIBER‐BBN) Camino de Vera s/n 46022 Valencia Spain

Center for Biomaterials and Tissue Engineering (CBIT) Universitat Politècnica de València Camino de Vera s/n 46022 Valencia Spain

Center for Cell Engineering Institute of Molecular Cell and Systems Biology CMVLS University of Glasgow Joseph Black Building Glasgow G12 8QQ UK

Division of Biomedical Engineering School of Engineering University of Glasgow Rankine Building Glasgow G12 8LT UK

References

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