Advanced biosensor for dopamine detection based on polyglutamic acid modified electrode

Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, P. R. China; C. Yao; Y. Zhang; Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, P. R. China; S. Zhang; Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, P. R. China; B. Shi; Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, P. R. China; J. Dang; Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, P. R. China; C. Zhao; Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, P. R. China; Q. Li; Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, P. R. China; H. Zhang; Henan Yingfeng Sensing Technology Co., LTD, Henan, P. R. China; R. Wang; Tianjin Branch of CNOOC Ltd, Tianjin, P. R. China

doi:10.15251/djnb.2025.204.1395

journal article·2025-11-15Open access

Advanced biosensor for dopamine detection based on polyglutamic acid modified electrode

Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, P. R. China, C. Yao, Y. Zhang, Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, P. R. China, S. Zhang, Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, P. R. China, B. Shi, Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, P. R. China, J. Dang, Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, P. R. China, C. Zhao, Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, P. R. China, Q. Li, Key Laboratory of Micro-Nano Materials for Energy Storage and Conversion of Henan Province, Institute of Surface Micro and Nano Materials, College of Chemical and Materials Engineering, Xuchang University, Henan 461000, P. R. China, H. Zhang, Henan Yingfeng Sensing Technology Co., LTD, Henan, P. R. China, R. Wang, Tianjin Branch of CNOOC Ltd, Tianjin, P. R. China

Digest Journal of Nanomaterials and Biostructures· Volume 20· Issue 4

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Source abstract

Abstract

Rapid and accurate dopamine (DA) detection is of great significance in clinical practice. In this study, polyglutamic acid modified graphite electrode (PGA/GE) was fabricated via onestep electrodeposition, and was employed to construct electrochemical sensor for DA detection. By systematic optimization, PGA/GE based sensor showed good performance with a wide linear range (0.5-120 μM) and especially a low limit of detection (0.0714 μM). Besides, PGA/GE base sensor presented many merits such as low cost, excellent reproducibility and anti-interference ability, allowing actual urine samples detection with a favorable recovery rate. So, PGA/GE based sensor has good application prospect in clinical diagnosis.

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Research context

OpenAlex topics: Electrochemical sensors and biosensors · Biological Research and Disease Studies · Polyamine Metabolism and Applications

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