Elsholtzia communis leaf extract mediated synthesis of silver nanoparticles: enhanced antioxidant, antidiabetic and antiproliferative activity
Source abstract
Abstract
Nanoparticles of silver were synthesised utilising water leaf extract of Elsholtzia communis (Collett and Hemsl.) Diels (ECO). The formation of Elsholtzia communis silver nanoparticles (ECO-AgNPs) was monitored by a UV-visible spectrophotometer. From the TEM and XRD analysis, the average particle and crystallite size of ECO-AgNPs was determined as 11.38 nm and 8.52 nm, respectively. DLS studies of ECO-AgNPs showed the ζ-potential value of −59.4 mV and a polydispersity index (PDI) of 0.149. The phytochemicals responsible for the reduction of silver ions were confirmed through FTIR spectroscopy and further supported by HRLC-MS analysis. Dose-dependent antioxidant and antidiabetic activities were demonstrated by the biosynthesized nanoparticles. The antiproliferative activity of ECO-AgNPs was estimated using 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT) assay on HeLa, HCT 116 and A549 cell lines and their IC50 values were found to be 71.33 ± 2.89 µg/mL, 33.45 ± 0.21 µg/mL, and 28.91 ± 5.01 µg/mL, respectively. The results showed that Elsholtzia communis AgNPs have enhanced antiproliferative, antioxidant, and antidiabetic activities and may be employed as beneficial nanocompounds.
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Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Nanotechnology research and applications · Laser-Ablation Synthesis of Nanoparticles
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References (32)
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1. [1] N. Baig, I. Kammakakam and W. Falath, Mater. Adv. 2, 1821 (2021); https://doi.org/10.1039/D0MA00807A10.1039/D0MA00807A ↗
2. [2] I. Khan, K. Saeed and I. Khan, Arabian Journal of Chemistry. 12, 908 (2019); https://doi.org/10.1016/j.arabjc.2017.05.01110.1016/j.arabjc.2017.05.011 ↗
3. [3] Hemlata, P. R. Meena, A. P. Singh, and K. K. Tejavath, ACS Omega. 5, 10 (2020); https://doi.org/10.1021/acsomega.0c00155[4] H. A. Widatalla, L. F. Yassin, A. A. Alrasheid, S. A. Rahman Ahmed and M. O. Widdatallah, Nanoscale Advances. 4, 911 (2022); https://doi.org/10.1039/D1NA00509J10.1039/D1NA00509J ↗
4. [5] L. V. Hublikar, S. V. Ganachari and V. B. Patil, Nanoscale Adv. 5, 4149 (2023); https://doi.org/10.1039/D3NA00313B10.1039/D3NA00313B ↗
5. [6] L. A. T. Nguyen, B. Van Mai, D. Van Nguyen, N. Q. T. Nguyen, V. Van Pham, T. L. M. Pham and H. T. Le, Green Processing and Synthesis. 12, 20230024 (2023); https://doi.org/10.1515/gps-2023-002410.1515/gps-2023-0024 ↗
6. [7] S. Sarkar and V. Kotteeswaran, Adv. Nat. Sci: Nanosci. Nanotechnol. 9, 025014 (2018); https://doi.org/10.1088/2043-6254/aac59010.1088/2043-6254/aac590 ↗
7. [8] M. Naveed et al., Molecules. 27, 4226 (2022); https://doi.org/10.3390/molecules2713422610.3390/molecules27134226 ↗
8. [9] S. Begum, K. D. Chanu, N. Sharma and R. K. London Singh, Asian J. Chem. 35, 732 (2023); https://doi.org/10.14233/ajchem.2023.2758310.14233/ajchem.2023.27583 ↗
9. [10] Z. Guo, Z. Liu, X. Wang, W. Liu, R. Jiang, R. Cheng and G. She, Chem Cent J. 6, 147 (2012); https://doi.org/10.1186/1752-153X-6-14710.1186/1752-153X-6-147 ↗
10. [11] S. D. Khomdram and P. K. Singh, Not Sci Biol. 3, 108 (2011); https://doi.org/10.15835/nsb32563810.15835/nsb325638 ↗
11. [12] Y. K. Yong, J. J. Tan, S. S. Teh, S. H. Mah, G. C. L. Ee, H. S. Chiong and Z. Ahmad, Clinacanthus Nutans Evidence-Based Complementary and Alternative Medicine. 2013, e462751 (2013); https://doi.org/10.1155/2013/46275110.1155/2013/462751 ↗
12. [13] R. A. Khan, M. R. Khan, S. Sahreen and M. Ahmed, Chemistry Central Journal. 6, 12 (2012); https://doi.org/10.1186/1752-153X-6-4310.1186/1752-153X-6-43 ↗
13. [14] N. G. E. R. Etsassala, J. A. Badmus, J. L. Marnewick, E. I. Iwuoha, F. Nchu and A. A. Hussein, Antioxidants. 9, 1149 (2020); https://doi.org/10.3390/antiox911114910.3390/antiox9111149 ↗
14. [15] B. M. I. S. Jadalla, J. J. Moser, R. Sharma, N. G. E. R. Etsassala, S. A. Egieyeh, J. A. Badmus, J. L. Marnewick, D. Beukes, C. N. Cupido and A. A. Hussein, Separations. 9, 190 (2022); https://doi.org/10.3390/separations908019010.3390/separations9080190 ↗
15. [16] R. Pungle, S. H. Nile, N. Makwana, R. Singh, R. P. Singh and A. S. Kharat, Oxidative Medicine and Cellular Longevity. 2022, 1 (2022); https://doi.org/10.1155/2022/967159410.1155/2022/9671594 ↗
16. [17] H. M. M. Ibrahim, Journal of Radiation Research and Applied Sciences. 8, 265 (2015); https://doi.org/10.1016/j.jrras.2015.01.00710.1016/j.jrras.2015.01.007 ↗
17. [18] R. Kumar, S. M. Roopan, A. Prabhakarn, V. G. Khanna and S. Chakroborty, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy. 90, 173 (2012); https://doi.org/10.1016/j.saa.2012.01.02910.1016/j.saa.2012.01.029 ↗
18. [19] S. M. Roopan, Rohit, G. Madhumitha, A. A. Rahuman, C. Kamaraj, A. Bharathi and T. V. Surendra, Industrial Crops and Products. 43, 631 (2013); https://doi.org/10.1016/j.indcrop.2012.08.01310.1016/j.indcrop.2012.08.013 ↗
19. [20] A. L. Patterson, Physical Review. 56, 978 (1939); https://doi.org/10.1103/PhysRev.56.97810.1103/PhysRev.56.978 ↗
20. [21] S. Sarkar and V. Kotteeswaran, Adv. Nat. Sci: Nanosci. Nanotechnol. 9, 025014 (2018); https://doi.org/10.1088/2043-6254/aac59010.1088/2043-6254/aac590 ↗
21. [22] G. Singhal, R. Bhavesh, K. Kasariya, A. R. Sharma and R. P. Singh, J Nanopart Res. 13, 2981 (2011); https://doi.org/10.1007/s11051-010-0193-y10.1007/s11051-010-0193-y ↗
22. [23] S. Wu, S. Rajeshkumar, M. Madasamy and V. Mahendran, Artificial Cells, Nanomedicine, and Biotechnology. 48, 1153 (2020); https://doi.org/10.1080/21691401.2020.181705310.1080/21691401.2020.1817053 ↗
23. [24] W. Suvandee, V. Teeranachaideekul, N. Jeenduang, P. Nooeaid, A. Makarasen, L. Chuenchom, S. Techasakul and D. Dechtrirat, Polymers. 14, 2205 (2022); https://doi.org/10.3390/polym1411220510.3390/polym14112205 ↗
24. [25] M. Ismail, S. Gul, M. I. Khan, M. A. Khan, A. M. Asiri and S. B. Khan, Green Processing and Synthesis 8, 118 (2019); https://doi.org/10.1515/gps-2018-0030[26] A. A. Fairuzi, N. N. Bonnia, R. M. Akhir, M. A. Abrani and H. M. Akil, IOP Conference Series: Earth and Environmental Science 105, 0 (2018); https://doi.org/10.1088/1755- 1315/105/1/012018
25. [27] S. Raj, H. Singh, R. Trivedi, and V. Soni, Sci Rep. 10(1), 9616 (2020); https://doi.org/10.1038/s41598-020-66851-810.1038/s41598-020-66851-8 ↗
26. [28] M. Vanaja, K. Paulkumar, M. Baburaja, S. Rajeshkumar, G. Gnanajobitha, C. Malarkodi, M. Sivakavinesan and G. Annadurai, Bioinorganic Chemistry and Applications. 2014, (2014); https://doi.org/10.1155/2014/74234610.1155/2014/742346 ↗
27. [29] E.-Y. Ahn, H. Jin, and Y. Park, Materials Science and Engineering: C. 101, 204 (2019); https://doi.org/10.1016/j.msec.2019.03.09510.1016/j.msec.2019.03.095 ↗
28. [30] N. Anil and V. Talluri, Rasayan Journal of Chemistry. 14, 2318 (2021); https://doi.org/10.31788/RJC.2021.144647310.31788/RJC.2021.1446473 ↗
29. [31] M. S. Abdel-Aziz, M. S. Shaheen, A. A. El-Nekeety, and M. A. Abdel-Wahhab, Journal of Saudi Chemical Society. 18, 356 (2014); https://doi.org/10.1016/j.jscs.2013.09.01110.1016/j.jscs.2013.09.011 ↗
30. [32] R. Mata, J. R. Nakkala, and S. R. Sadras, Colloids and Surfaces B: Biointerfaces. 128, 276 (2015); https://doi.org/10.1016/j.colsurfb.2015.01.05210.1016/j.colsurfb.2015.01.052 ↗
31. [33] K. Rajaram, D. C. Aiswarya, and P. Sureshkumar, Materials Letters. 138, 251 (2015); https://doi.org/10.1016/j.matlet.2014.10.01710.1016/j.matlet.2014.10.017 ↗
32. [34] N. E.-A. El-Naggar, M. H. Hussein, and A. A. El-Sawah, Sci Rep. 7, 1 (2017); https://doi.org/10.1038/s41598-017-11121-310.1038/s41598-017-11121-3 ↗