DataVXAdvanced Functional MaterialsPaper
journal article·2021-07

Human Macrophage Invasion: Gelatin‐Hyaluronan Click‐Crosslinked Cryogels Elucidate Human Macrophage Invasion Behavior (Adv. Funct. Mater. 28/2021)

Laura C. Bahlmann, Alexander E. G. Baker, Chang Xue, Sophie Liu, Moritz Meier‐Merziger, Danielle Karakas, Luke Zhu, Ileana Co, Spencer Zhao, Allysia Chin, Alison McGuigan, John Kuruvilla, Rob C. Laister, Molly S. Shoichet

Advanced Functional Materials· Volume 31· Issue 28
Publisher page
Source abstract

Abstract

In article number 2008400, Molly S. Shoichet and co-workers demonstrate macrophage invasion into an oxime-crosslinked cryogel comprised of gelatin-oxyamine and hyaluronan-aldehyde. The macrophages migrate by actively degrading the matrix and through the pores. IL4/IL13-stimulated cells (flat cells) migrate further than IFNγ/LPS-stimulated cells (spikey cells). These cryogels allow for emulating the extracellular environment of cancer—a key parameter in macrophage invasion. Image concept by Laura Bahlmann and created by Ella Maru Studio.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Immune cells in cancer

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Affiliations

Institute of Biomedical Engineering 164 College Street Toronto Ontario M5S 3G9 Canada

The Donnelly Centre University of Toronto 160 College St Toronto Ontario M5S 3E1 Canada

Department of Chemical Engineering and Applied Chemistry University of Toronto 200 College Street Toronto Ontario M5S 3E5 Canada

Department of Chemistry Johannes Gutenberg University Duesbergweg 10‐14 55128 Mainz Germany

Princess Margaret Cancer Centre University Health Network 610 University Ave Toronto Ontario M5G 2C1 Canada

Department of Chemistry University of Toronto 80 St. George Street Toronto Ontario M5S 3H6 Canada

References

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