DataVXAdvanced Functional MaterialsPaper
journal article·2019-04Open access

Nanotopography: Nanotopography‐Induced Unfolding of Fibrinogen Modulates Leukocyte Binding and Activation (Adv. Funct. Mater. 14/2019)

Rahul M. Visalakshan, Alex A. Cavallaro, Melanie N. MacGregor, Emma P. Lawrence, Kaloian Koynov, John D. Hayball, Krasimir Vasilev

Advanced Functional Materials· Volume 29· Issue 14
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Source abstract

Abstract

In article number 1807453, Krasimir Vasilev and co-workers describe the role of surface nanotopography in modulating immune responses. By using model surfaces purposely engineered at the nanoscale, the team demonstrates nanotopography scale dependent fibrinogen unfolding, which leads to the exposure of normally hidden peptide sequences causing activation of the Mac-1 receptor of inflammatory cells.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Blood properties and coagulation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Engineering University of South Australia Mawson Lakes SA 5095 Australia

Future Industries Institute University of South Australia Mawson Lakes SA 5095 Australia

Mechanisms in Cell Biology and Disease Research Group University of South Australia Cancer Research Institute Adelaide SA 5000 Australia

Max Planck Institute for Polymer Research Ackermannweg 10 Mainz 55128 Germany

School of Pharmacy and Medical Sciences University of South Australia Adelaide SA 5001 Australia

Experimental Therapeutics Laboratory University of South Australia Cancer Research Institute Adelaide SA 5000 Australia

Robinson Research Institute and Adelaide Medical School University of Adelaide Adelaide SA 5005 Australia

References

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