Designing and fabrication of electrochemical nanosensor employing fullerene-C60 and bimetallic nanoparticles composite film for the detection of vitamin D3 in blood samples
Source abstract
Abstract
Abstract Designing an accurate, selective and easy to operate the electrochemical analytical device for versatile applications is an important challenge for today and tomorrow's biomedical science. Electrochemical oxidation of Vitamin D at a bare electrode is poor. To enhance the oxidation of vitamin D and determine its concentration in blood samples, herein we propose fullerene-C60 and copper‑nickel bimetallic nanoparticles nanocomposite film modified glassy carbon electrode as an electrochemical sensor. Fullerene-C60 was manually dropped at GCE by a drop-casting method and then CuNPs and NiNPs were electrochemically deposited on fullerene modified GCE. The developed sensor was characterized by electrochemically and morphologically. The nanocomposite film of CuNPs-NiNPs@reduced-fullerene-C60 on GCE exhibited a well-defined oxidation peak for the detection of vitamin D3 with a high dynamic concentration range of 1.25–475 μM and limit of detection of 0.0025 μM. The influence of solvents, supporting electrolytes and composition of solvent on the electrochemical performance of the sensor was evaluated. Various kinetics parameters were also evaluated. Finally, the fabricated sensor employed for real samples that showed satisfactory results for the detection of vitamin D3 in clinical and pharmaceutical samples.
Source: openaire · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Vitamin D Research Studies · Electrochemical sensors and biosensors · Electrochemical Analysis and Applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (52)
Show source-provided references
1. Vitamin D: the more we know, the less we know10.1373/clinchem.2014.222521 ↗
2. A simple and precise LC-MS/MS method for simultaneous determination of serum 25-hydroxyvitamin D3 and D2 without interference from the C3 epimer10.1039/C5AY00971E ↗
3. Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D10.1080/07315724.2003.10719287 ↗
4. Estimates of optimal vitamin D status10.1007/s00198-005-1867-7 ↗
5. Determination of vitamin D and its metabolites10.1016/j.beem.2013.06.001 ↗
6. Current status of clinical 25-hydroxyvitamin D measurement: an assessment of between-laboratory agreement10.1016/j.cca.2010.08.018 ↗
7. Surfactant enhanced flow injection chemiluminescence method for vitamin D3 determination in pharmaceutical formulations10.1016/j.saa.2018.10.001 ↗
8. HPLC determination of Vitamin D3 and its metabolite in human plasma with on-line sample cleanup10.1016/j.talanta.2004.04.035 ↗
9. The determination of 2β-(3-hydroxy-propoxy)-1α-25-dihydroxy vitamin D3(ED-71) in human serum by high -performance liquid chromatography-electrospray tandem mass spectroscopy10.1016/j.jchromb.2004.10.066 ↗
10. A novel high-performance liquid chromatographic assay for vitamin D metabolites using a coulometric electrochemical detector10.1016/S0731-7085(96)02005-5 ↗
11. E.J. Dufek, B. Ehlert, M.C. Granger, T.M. Sandrock, S.L. Legge, M.G. Herrmann, M.D. Porter, Competitive surface-enhanced Raman scattering assay for the 1,25-dihydroxy metabolite of vitamin D3, Analyst. 135(11) 2811.10.1039/c0an00354a ↗
12. Design of electrochemically modified fMWCNT-pencil graphite electrode decorated with Cu and Ag nanofilm and its electrocatalytic behavior towards imazethapyr10.1002/elan.201700128 ↗
13. Design of electrochemical sensor based on fMWCNT-CPE decorated with Ti nanofilm and its electrocatalytic behavior towards aminotriazole10.1007/s12678-017-0358-x ↗
14. Development of Prussian Blue and Fe(bpy)32+ hybrid modified pencil graphite electrodes utilizing its intrinsic iron for electroanalytical applications10.1016/j.jelechem.2017.01.028 ↗
15. Simultaneous voltammetric determination of paracetamol and domperidone based on a graphene/platinum nanoparticles/nafion composite modified glassy carbon electrode10.1016/j.snb.2015.02.090 ↗
16. Chitosan/polyaniline hybrid conducting biopolymer base impedimetric immunosensor to detect Ochratoxin-A10.1016/j.bios.2008.08.046 ↗
17. Karimi-Maleh · Biosens. Bioelectron. · 2013 · 48 · 27010.1016/j.bios.2013.04.029 ↗
18. Fullerene-C60 sensor for ultra-high sensitive detection of bisphenol-A and its treatment by green technology10.1016/j.snb.2012.08.081 ↗
19. Fullerene-C60-modified edge plane pyrolytic graphite electrode for the determination of dexamethasone in pharmaceutical formulations and human biological fluids10.1016/j.bios.2008.08.024 ↗
20. Electrochemical immunosensor based on magnetite nanoparticles incorporated into electro spun polyacrylonitrile nanofibers for vitamin-D3 detection10.1016/j.msec.2018.07.036 ↗
21. K. Men, Y. Chen, J. Liu and D. Wei, Electrochemical detection of vitamin d2 and vitamin d3 based on Au-Pd modified glassy carbon electrode, Int. J. Electrochem. Sci.. 12(2071) 9555–9564.10.20964/2017.10.15 ↗
22. Voltammetric determination of cholecalciferol at glassy carbon electrode performed in water-ethanol mixture10.5219/889 ↗
23. A novel immunosensor based on fullerene C60 for electrochemical analysis of heat shock protein 7010.1016/j.jelechem.2016.11.020 ↗
24. Preparation of highly stable fullerene C60 decorated graphene oxide nanocomposite and its sensitive electrochemical detection of dopamine in rat brain and pharmaceutical samples10.1016/j.jcis.2015.10.009 ↗
25. A new fullerene-C60–nanogold composite for non-enzymatic glucose sensing10.1016/j.snb.2016.10.111 ↗
26. Electrochemical sensor for the determination of dopamine in presence of high concentration of ascorbic acid using a fullerene-C60 coated gold electrode10.1002/elan.200704073 ↗
27. Highly catalytical performance of nano porous copper for electro-oxidation of methanol in alkaline media10.1016/j.matchemphys.2018.07.034 ↗
28. Nonenzymatic glucose sensor based on disposable pencil graphite electrode modified by copper nanoparticles10.1016/j.jfda.2016.02.010 ↗
29. A new non-enzymatic glucose sensor based on copper/porous silicon nanocomposite10.1016/j.electacta.2014.01.031 ↗
30. Determination of lead with a copper-based electrochemical sensor10.1021/acs.analchem.6b03894 ↗
31. Amperometric paper sensor based on Cu nanoparticles for the determination of carbohydrates10.1016/j.snb.2017.01.064 ↗
32. Highly sensitive nonenzymatic glucose sensor based on nickel nanoparticle — attapulgite-reduced graphene oxide-modified glassy carbon electrode10.1016/j.talanta.2016.06.016 ↗
33. Nickel-reduced graphene oxide composite foams for electrochemical oxidation processes: towards biomolecule sensing
34. Fabrication of Co-Ni alloy nanostructures on copper foam for highly sensitive amperometric sensing of acetaminophen10.1016/j.jelechem.2018.05.009 ↗
35. Study of Ag–Pd bimetallic nanoparticles modified glassy carbon electrode for detection of l-cysteine10.1016/j.spmi.2014.09.025 ↗
36. Green synthesized Au–Ag bimetallic nanoparticles modified electrodes for the amperometric detection of hydrogen peroxide10.1007/s10800-010-0188-5 ↗
37. A highly sensitive nonenzymatic glucose sensor based on multi-walled carbon nanotubes decorated with nickel and copper nanoparticles10.1016/j.electacta.2013.02.098 ↗
38. Use of interelectrode material transfer of nickel and copper nickel alloy to carbon fibers to assemble miniature glucose sensors10.1016/j.jelechem.2018.03.039 ↗
39. Fabrication of highly sensitive and selective nanocomposite film based on CuNPs/fullerene-C60/MWCNTs: an electrochemical nano sensor for trace recognition of paracetamol10.1016/j.aca.2016.02.044 ↗
40. Effect of carbon nanotube and graphene oxide on the electrocatalytic behavior of Ni-W alloy for hydrogen evolution reaction10.1039/C7NJ02722B ↗
41. Mild hydrothermal synthesis of Ni–Cu nanoparticles
42. Nonenzymatic glucose sensor with high performance electrodeposited nickel/copper/carbon nanotubes nanocomposite electrode10.1016/j.jpcs.2018.04.015 ↗
43. Palladium nanoparticles decorated on activated fullerene modified screen printed carbon electrode for enhanced electrochemical sensing of dopamine10.1016/j.jcis.2015.02.013 ↗
44. Electrocatalytic oxidation of hydrazine at glassy carbon electrode modified with ethylenediamine cellulose immobilized palladium nanoparticles10.1016/j.jelechem.2012.11.031 ↗
45. Fabrication of silver nanoparticles–polypyrole composite modified electrode for electrocatalytic oxidation of hydrazine10.1016/j.synthmet.2014.06.014 ↗
46. Development of electrochemical method for the determination of chlorzoxazone drug and its analytical applications to pharmaceutical dosage form and human biological fluids10.1021/ie2021812 ↗
47. Bard · 2004
48. Prodromidis · Electroanalysis · 2000 · 12 · 149810.1002/1521-4109(200012)12:18<1498::AID-ELAN1498>3.0.CO;2-Y ↗
49. Highly sensitive electrochemical sensor for determination of vitamin D in mixtures of water-ethanol10.1002/elan.201400451 ↗
50. Synthesis and characterization of α-nickel (II) hydroxide particles on organic-inorganic matrix and its application in a sensitive electrochemical sensor for vitamin D determination10.1016/j.electacta.2014.10.012 ↗
51. Voltammetric behaviour of vitamins D2 and D3 at a glassy carbon electrode and their determination in pharmaceutical products by using liquid chromatography with amperometric detection10.1039/an9921701441 ↗
52. Voltammetry of the liposoluble vitamins (A, D, E and K) in organic solvents10.1002/tcr.201100005 ↗