DataVXAdvanced Functional MaterialsPaper
journal article·2019-05Open access

Lung‐Targeted Rnai Therapeutics: Lung‐Endothelium‐Targeted Nanoparticles Based on a pH‐Sensitive Lipid and the GALA Peptide Enable Robust Gene Silencing and the Regression of Metastatic Lung Cancer (Adv. Funct. Mater. 18/2019)

Mahmoud M. Abd Elwakil, Ikramy A. Khalil, Yaser H. A. Elewa, Kenji Kusumoto, Yusuke Sato, Nour Shobaki, Yasuhiro Kon, Hideyoshi Harashima

Advanced Functional Materials· Volume 29· Issue 18
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Source abstract

Abstract

Engineering nanocarrier systems for efficient small interfering RNA (siRNA) delivery requires advanced materials that can achieve specific cellular targeting together with efficient intracellular trafficking for reaching target sites in the cytosol. In article number 1807677, Ikramy A. Khalil, Hideyoshi Harashima, and co-workers use nanoparticles modified with the GALA peptide as targeted therapy for the lung endothelium, resulting in a robust gene knockdown. The nanoparticles are successfully applied for the regression of metastatic lung cancer.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: RNA Interference and Gene Delivery · Advanced biosensing and bioanalysis techniques · RNA modifications and cancer

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Affiliations

Laboratory of Innovative Nanomedicine Faculty of Pharmaceutical Sciences Hokkaido University Kita‐12, Nishi‐6, Kita‐ku Sapporo Hokkaido 060‐0812 Japan

Department of Pharmaceutics Faculty of Pharmacy Assiut University Assiut 71526 Egypt

Department of Histology and Cytology Faculty of Veterinary Medicine Zagazig University Zagazig 44511 Egypt

Laboratory of Anatomy Department of Biomedical Sciences Graduate School of Veterinary Medicine Hokkaido University Kita 18, Nishi 9, Kita‐ku Sapporo 060‐0818 Japan

Formulation Research Lab. Taiho Pharmaceutical Co., Ltd. 224‐2, Ebisuno, Hiraishi, Kawauchi‐cho Tokushima 771‐0194 Japan

Laboratory for Molecular Design of Pharmaceutics Faculty of Pharmaceutical Sciences Hokkaido University Sapporo Hokkaido 060‐0812 Japan

References

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