DataVXAdvanced Functional MaterialsPaper
journal article·2024-01Open access

Highly Deformable Double‐Sided Neural Probe with All‐in‐One Electrode System for Real‐Time In Vivo Detection of Dopamine for Parkinson's Disease (Adv. Funct. Mater. 4/2024)

Han Hee Jung, Jeongdae Ha, Jeongrak Park, Seongtak Kang, Jinmo Kim, Han Na Jung, Samhwan Kim, Junwoo Yea, Hyeokjun Lee, Saehyuck Oh, Janghwan Jekal, Soojeong Song, Jieun Son, Tae Sang Yu, Youngjeon Lee, Jinyoung Won, Kyung Seob Lim, Yoon Kyeung Lee, Hohyun Keum, Taeyoon Lee, Young Min Song, Jae‐Woong Jeong, Jong‐Cheol Rah, Ji‐Woong Choi, Sheng Xu, Yong‐Seok Oh, Kyung‐In Jang

Advanced Functional Materials· Volume 34· Issue 4
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Source abstract

Abstract

Neural Probes In article number 2311436, Yong-Seok Oh, Kyung-In Jang, and co-workers present a multi-deformable double-sided (MDD) probe that facilitates real-time dopamine monitoring in the brain. The all-in-one probe integrates working, reference, and counter electrodes, achieving high sensitivity and selectivity through enzyme immobilization on ZnO nanorods. Its serpentine design ensures stretchability and stress management. Successful rodent implantation enables reliable in-vivo monitoring of dopamine dynamics, including assessing L-DOPA treatment effects in hemi-PD mice.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: Conducting polymers and applications · Neuroscience and Neural Engineering · Electrochemical sensors and biosensors

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Affiliations

Department of Robotics and Mechatronics Engineering Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu 42988 Republic of Korea

Brain Engineering Convergence Research Center Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu 42988 Republic of Korea

Department of Brain Sciences Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu 42988 Republic of Korea

Department of Neurology University of California San Diego La Jolla CA 92093 USA

Department of Electrical Engineering and Computer Science Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu 42988 Republic of Korea

Department of Applied Bioengineering Graduate School of Convergence Science and Technology Seoul National University Seoul 08826 Republic of Korea

National Primate Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) Daejeon 28116 Republic of Korea

Futuristic Animal Resource and Research Center Korea Research Institute of Bioscience and Biotechnology (KRIBB) Daejeon 28116 Republic of Korea

Division of Advanced Materials Engineering Jeonbuk National University Jeonju Jeonbuk 54896 Republic of Korea

Digital Health Care R&D Department Korea Institute of Industrial Technology Cheonan Chungnam 31056 Republic of Korea

School of Electrical and Electronic Engineering Yonsei University Seoul 03722 Republic of Korea

School of Electrical Engineering and Computer Science Gwangju Institute of Science and Technology Gwangju 61005 Republic of Korea

School of Electrical Engineering Korea Advanced Institute of Science and Technology Daejeon 34141 Republic of Korea

Korea Brain Research Institute Daegu 41062 Republic of Korea

Department of Nanoengineering University of California San Diego La Jolla CA 92093 USA

Artificial Intelligence Major in Department of Interdisciplinary Studies Daegu Gyeongbuk Institute of Science and Technology (DGIST) Daegu 42988 Republic of Korea

References

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