DataVXAdvanced Functional MaterialsPaper
journal article·2022-07Open access

Receptor‐Level Proximity and Fastening of Ligands Modulates Stem Cell Differentiation (Adv. Funct. Mater. 30/2022)

Gunhyu Bae, Myeong Soo Kim, Ramar Thangam, Thomas Myeongseok Koo, Woo Young Jang, Jinho Yoon, Seong‐Beom Han, Letao Yang, Seong Yeol Kim, Nayeon Kang, Sunhong Min, Hyunsik Hong, Hong En Fu, Min Jun Ko, Dong‐Hwee Kim, Woong Kyo Jeong, Dong‐Hyun Kim, Tae‐Hyung Kim, Jeong‐Woo Choi, Ki‐Bum Lee, Ramasamy Paulmurugan, Yangzhi Zhu, Han‐Jun Kim, Junmin Lee, Jong Seung Kim, Ali Khademhosseini, Young Keun Kim, Heemin Kang

Advanced Functional Materials· Volume 32· Issue 30
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Source abstract

Abstract

Integrin Clustering In article number 2200828, Young Keun Kim, Heemin Kang, and co-workers report the dynamic tuning of receptor-level ligand proximity. Closely spaced ligands coated onto subordinate nanostructures distributed on a nano-template stimulate integrin binding and clustering. This activates the spreading, mechanotransduction, and differentiation of stem cells that occur in an active pro-regenerative microenvironment.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Cell Adhesion Molecules Research

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Affiliations

Department of Materials Science and Engineering Korea University Seoul 02841 Republic of Korea

Institute for High Technology Materials and Devices Korea University Seoul 02841 Republic of Korea

Department of Orthopedic Surgery Korea University Anam Hospital Seoul 02841 Republic of Korea

Department of Chemistry and Chemical Biology Rutgers University Piscataway NJ 08854 USA

Department of Chemical and Biomolecular Engineering Sogang University Seoul 04107 Republic of Korea

KU‐KIST Graduate School of Converging Science and Technology Korea University Seoul 02841 Republic of Korea

Department of Radiology Feinberg School of Medicine Northwestern University Chicago IL 60208 USA

School of Integrative Engineering Chung‐Ang University Seoul 06974 Republic of Korea

Department of Radiology Molecular Imaging Program at Stanford Stanford University School of Medicine Stanford University Palo Alto CA 94304 USA

Department of Radiology Canary Center at Stanford for Cancer Early Detection Stanford University School of Medicine Stanford University Palo Alto CA 94304 USA

Terasaki Institute for Biomedical Innovation Los Angeles CA 90064 USA

Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH) Pohang 37673 Republic of Korea

Department of Chemistry Korea University Seoul 02841 Republic of Korea

Department of Biomicrosystem Technology Korea University Seoul 02841 Republic of Korea

References

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