DataVXAdvanced Functional MaterialsPaper
journal article·2020-03Open access

Dendrimer‐Based Nanosensitizers: Targeted Tumor Hypoxia Dual‐Mode CT/MR Imaging and Enhanced Radiation Therapy Using Dendrimer‐Based Nanosensitizers (Adv. Funct. Mater. 13/2020)

Yu Fan, Wenzhi Tu, Mingwu Shen, Xuming Chen, Yuesheng Ning, Junjun Li, Tingfeng Chen, Han Wang, Fangfang Yin, Yong Liu, Xiangyang Shi

Advanced Functional Materials· Volume 30· Issue 13
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Source abstract

Abstract

In article number 1909285, Yong Liu, Xiangyang Shi, and co-workers report hypoxia-targeted dendrimer-based nanodevices, which can be employed as a contrast agent for dual mode CT/MR imaging of hypoxic tumors. Moreover, under X-ray irradiation, the developed nanohybrids enable enhanced reactive oxygen species production, promote DNA damage, and prevent DNA repair, facilitating sensitized radiotherapy of hypoxic tumors in vivo.
Source: openalex_inverted_index · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Cancer, Hypoxia, and Metabolism · Advanced Computing and Algorithms

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Affiliations

State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 P. R. China

Department of Radiation Oncology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai 201620 P. R. China

State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200240 P. R. China

Department of Radiology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200080 P. R. China

References

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