Comparison of the cytogenotoxicity induced by five different dental alloys using four in vitro assays
Source abstract
Abstract
The purpose of present investigation was to compare the cyto-genotoxicity induced by five dental alloys in vitro. The cyto-genotoxicity induced by five dental alloy extracts on human B lymphoblast cells was assessed with neutral red uptake (NRU) , CCK-8, comet and micronucleus (CBMN) assays in vitro, respectively. The results of in vitro comet and CBMN assays indicated that DNA damage (% tail DNA) and micronucleus frequencies (MNFs) in all exposure groups did not significantly increase, as compared with the control group. However, the results of NRU and CCK-8 assays demonstrated that there were to some extent differences in the cytotoxicity among 5 dental alloy extracts in vitro. The cytotoxicity may be relevant to the Ni and Be ions released in the alloy extract.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Carcinogens and Genotoxicity Assessment · Heavy Metal Exposure and Toxicity
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Zhejiang University, Stomatology Hospital of Medical College
Zhejiang University, Medical College, Institute of Environmental Medicine
Zhejiang Chinese Medical University, College of Stomotology
Hangzhou Center for Disease Control and Prevention
References (33)
Show source-provided references
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