In vitro evaluation of NaOCl-mediated functionalization of biologically aged titanium surfaces
Source abstract
Abstract
The aim of this study was to evaluate the NaOCl-mediated biofunctionalization of titanium surfaces. Titanium disks stored for 2 weeks were immersed in 5% NaOCl solution for 24 h. A disk immersed in distilled water for 24 h was used as a control. X-ray photoelectron spectrometer assay of the titanium surface after NaOCl treatment demonstrated that organic contaminants containing carbon and nitrogen were removed and the number of hydroxyl groups increased. The NaOCl treatment substantially converted the titanium surface to superhydrophilic status (θ<5°), which resulted in an increased number of attached cells and enhanced cell spreading on the NaOCl-treated surfaces. These results indicate that biofunctionalization of the biologically degraded titanium surfaces can be achieved by chemical surface treatment with 5% NaOCl. The mechanism for desorption of strongly adsorbed organic molecules with polar groups such as amino and aldehyde groups from titanium surfaces by ClO− was elucidated.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental Implant Techniques and Outcomes · Dental Trauma and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Division of Periodontology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido
Division of Geriatric Dentistry, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido
Division of Biomaterials and Bioengineering, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido
References (32)
Show source-provided references
1. 1) Albrektsson T, Brånemark PI, Hansson HA, Lindström J.Osseointegrated titanium implants: requirements for ensuring a long-lasting, direct bone-to-implant anchorage in man. Acta Orthop Scand 1981; 52: 155-170.10.3109/17453678108991776 ↗
2. 2) Weinlaender M, Kenney EB, Lekovic V, Beumer III J, Moy PK, Lewis S. Histomorphometry of bone apposition around three types of endosseous dental implants. Int J Oral Maxillofac Implants 1992; 7: 491-496.
3. 3) Ogawa T, Nishimura I. Different bone integration profiles of turned and acid-etched implants associated with modulated expression of extracellular matrix genes. Int J Oral Maxillofac Implants 2003; 18: 200-210.
4. 4) Att W, Hori N, Takeuchi M, Ouyang J, Yang Y, Anpo M, et al. Time-dependent degradation of titanium osteoconductivity: an implication of biological aging of implant materials. Biomaterials 2009; 30: 5352-5363.10.1016/j.biomaterials.2009.06.040 ↗
5. 5) Serro A, Saramago B. Influence of sterilization on the mineralization of titanium implants induced by incubation in various biological model fluids. Biomaterials 2003; 24: 4749-4760.10.1016/S0142-9612(03)00372-7 ↗
6. 6) Kilpadi DV, Lemons JE, Liu J, Raikar GN, Weimer JJ, Vohra Y.Cleaning and heat-treatment effects on unalloyed titanium implant surfaces. Int J Oral Maxillofac Implants 2000; 15: 219-230.
7. 7) Lee JH, Ogawa T. The biological aging of titanium implants. Implant Dent 2012; 21: 415-421.10.1097/ID.0b013e31826a51f4 ↗
8. 8) Suzuki T, Hori N, Att W, Kubo K, Iwasa F, Ueno T, et al. Ultraviolet treatment overcomes time-related degrading bioactivity of titanium. Tissue Engin Part A 2009; 15: 3679-3688.10.1089/ten.tea.2008.0568 ↗
9. 9) Aita H, Hori N, Takeuchi M, Suzuki T, Yamada M, Anpo M, et al. The effect of ultraviolet functionalization of titanium on integration with bone. Biomaterials 2009; 30: 1015-1025.10.1016/j.biomaterials.2008.11.004 ↗
10. 10) Ueno T, Takeuchi M, Hori N, Iwasa F, Minamikawa H, Igarashi Y, et al. Gamma ray treatment enhances bioactivity and osseointegration capability of titanium. J Biomed Mater Res B Appl Biomater 2012; 100: 2279-2287.10.1002/jbm.b.32799 ↗
11. 11) Nishiguchi S, Kato H, Fujita H, Kim HM, Miyaji F, Kokubo T, et al. Enhancement of bone-bonding strengths of titanium alloy implants by alkali and heat treatments. J Biomed Mater Res 1999; 48: 689-696.10.1002/(SICI)1097-4636(1999)48:5<689::AID-JBM13>3.0.CO;2-C ↗
12. 12) Duske K, Koban I, Kindel E, Schröder K, Nebe B, Holtfreter B, et al. Atmospheric plasma enhances wettability and cell spreading on dental implant metals. J Clin Periodontol 2012; 39: 400-407.10.1111/j.1600-051X.2012.01853.x ↗
13. 13) Yoshinari M, Matsuzaka K, Inoue T. Surface modification by cold-plasma technique for dental implants—Bio-functionalization with binding pharmaceuticals. Jpn Dent Sci Rev 2011; 47: 89-101.10.1016/j.jdsr.2011.03.001 ↗
14. 14) Kono M, Aita H, Ichioka Y, Kado T, Endo K, Koshino H. NaOCl-mediated biofunctionalization enhances bone-titanium integration. Dent Mater J 2015; 34: 537-544.10.4012/dmj.2015-010 ↗
15. 15) Healy KE, Ducheyne P. Hydration and preferential molecular adsorption on titanium in vitro. Biomaterials 1992; 13: 553-561.10.1016/0142-9612(92)90108-Z ↗
16. 16) Endo K. Chemical modification of metallic implant surfaces with biofunctional proteins. Dent Mater J 1995; 14: 185-198, 277.10.4012/dmj.14.185 ↗
17. 17) Boehm H. Acidic and basic properties of hydroxylated metal oxide surfaces. Discuss Faraday Soc 1971; 52: 264-275.10.1039/df9715200264 ↗
18. 18) Sham T, Lazarus M. X-ray photoelectron spectroscopy (XPS) studies of clean and hydrated TiO2 (rutile) surfaces. Chem Phys Lett 1979; 68: 426-432.10.1016/0009-2614(79)87231-0 ↗
19. 19) Ohno H, Endo K, Yamane Y, Kawashima I. Adhesion of adhesive resin to dental precious metal alloys. Part II. The relationship between surface structure of Au-In alloys and adhesive ability with 4-META resin. Dent Mater J 1998; 17: 285-293.10.4012/dmj.17.285 ↗
20. 20) Minamikawa H, Att W, Ikeda T, Hirota M, Ogawa T. Longterm progressive degradation of the biological capability of titanium. Materials 2016; 9: 102.10.3390/ma9020102 ↗
21. 21) Brimblecombe P. Air composition and chemistry: Cambridge University Press; 1996.
22. 22) Legreid G, Lööv JB, Staehelin J, Hueglin C, Hill M, Buchmann B, et al. Oxygenated volatile organic compounds (OVOCs) at an urban background site in Zürich (Europe): Seasonal variation and source allocation. Atmos Environ 2007; 41: 8409-8423.10.1016/j.atmosenv.2007.07.026 ↗
23. 23) Mellouki A, Wallington T, Chen J. Atmospheric chemistry of oxygenated volatile organic compounds: impacts on air quality and climate. Chem Rev 2015; 115: 3984-4014.10.1021/cr500549n ↗
24. 24) Allen K, Walker M, Leonard RG, Brennan M, Quigley K, Heatley D, et al. Adhesion and adhesives: the analytical challenge. Analytical proceedings 1992; 29: 389-398.10.1039/ap9922900389 ↗
25. 25) Kinloch A. Adhesion and adhesives chapman and hall. New York 1987.10.1007/978-94-015-7764-9 ↗
26. 26) Lee LH. Roles of molecular interactions in adhesion, adsorption, contact angle and wettability. J Adhes Sci Technol 1993; 7: 583-634.10.1163/156856193X00871 ↗
27. 27) Mohammadi Z. Sodium hypochlorite in endodontics: an update review. Int Dent J 2008; 58: 329-341.10.1111/j.1875-595X.2008.tb00354.x ↗
28. 28) Mountouris G, Silikas N, Eliades G. Effect of sodium hypochlorite treatment on the molecular composition and morphology of human coronal dentin. J Adhes Dent 2004; 6: 175-182.
29. 29) Hawkins C, Pattison D, Davies MJ. Hypochlorite-induced oxidation of amino acids, peptides and proteins. Amino Acids 2003; 25: 259-274.10.1007/s00726-003-0016-x ↗
30. 30) Schenk RK, Buser D. Osseointegration: a reality. Periodontol 2000 1998; 17: 22-35.10.1111/j.1600-0757.1998.tb00120.x ↗
31. 31) Feng B, Weng J, Yang B, Qu S, Zhang X. Characterization of surface oxide films on titanium and adhesion of osteoblast. Biomaterials 2003; 24: 4663-4670.10.1016/S0142-9612(03)00366-1 ↗
32. 32) Jansen J, Van Der Waerden J, De Groot K. Fibroblast and epithelial cell interactions with, surface-treated implant materials. Biomaterials 1991; 12: 25-31.10.1016/0142-9612(91)90127-V ↗