Carbon nanohorn coating on titanium promotes M2 macrophage polarization
Source abstract
Abstract
This study investigated the effects of carbon nanohorns (CNHs) coated on titanium surfaces on macrophage responses. The CNHs were electrodeposited on titanium discs to create a uniform coating with a thickness of 0.2-0.3 µm. Analysis of macrophages cultured on CNH-modified titanium (CNH/Ti) revealed decreased production of pro-inflammatory cytokines (TNFα and IL6) and increased IL10 gene expression compared to unmodified titanium. Immunofluorescence analysis showed higher expression of the M2 marker CD206 and lower expression of the M1 marker CD86 on the CNH/Ti surfaces. Gene expression analysis indicated downregulation of genes involved in DNA transcription, repair, and replication, correlating with controlled cell proliferation on CNH/Ti. These findings demonstrate that CNH modification on titanium surfaces influences macrophage cytokine production and phenotype marker expression, suggesting its potential application in dental implant development.
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Research context
OpenAlex topics: Graphene and Nanomaterials Applications · Nanoparticles: synthesis and applications · Vitamin D Research Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Oral Functional Prosthodontics, Faculty and Graduate School of Dental Medicine, Hokkaido University
Research Institute for Electronic Science, Hokkaido University
Graduate School of Environmental Science, Hokkaido University
Division of Preventive Dentistry, Department of Oral Medicine, School of Dentistry, Iwate Medical University
Support Section for Education and Research, Faculty of Dental Medicine, Hokkaido University
Graduate School of Advanced Science and Technology, Japan Advanced Institute of Science and Technology (JAIST)
Faculty of Science and Technology, Meijo University
References (28)
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