Development of a novel bioactive titanium membrane with alkali treatment for bone regeneration
Source abstract
Abstract
This study evaluates a bioactive titanium membrane with alkali treatment for stimulating apatite formation and promoting bone regeneration. The titanium thin membranes were either treated with NaOH (alkali-group) or untreated (control). Each sample were incubated in simulated body fluid. Subsequently, the composition of the surface calcium deposition, its weight increase ratio, and optical absorbance were evaluated. Then, the bone defect was trephined on the rats calvaria and covered with each sample membrane or no membrane, and the bone tissue area ratio (BTA) and bone membrane contact ratio (BMC) were evaluated. The spherical crystalline precipitates formed in both groups. In the alkali-group after 21 days, the precipitates matured, forming apatite-like precipitates. The alkali-group showed higher Ca and P contents and weight increase ratios than the control. The alkali-group exhibited a higher BMC than the control in the central area. Thus, this novel membrane has high apatite-forming and bone regeneration abilities.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Bone Tissue Engineering Materials · Dental Implant Techniques and Outcomes · Orthopaedic implants and arthroplasty
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Advanced Prosthodontics, Hiroshima University Graduate School of Biomedical Sciences
References (30)
Show source-provided references
1. 1) Degidi M, Scarano A, Piattelli A. Regeneration of the alveolar crest using titanium micromesh with autologous bone and a resorbable membrane. J Oral Implantol 2003; 29: 86-90.10.1563/1548-1336(2003)029<0086:ROTACU>2.3.CO;2 ↗
2. 2) Her S, Kang T, Fien MJ. Titanium mesh as an alternative to a membrane for ridge augmentation. J Oral Maxillofac Surg 2012; 70: 803-810.10.1016/j.joms.2011.11.017 ↗
3. 3) Rakhmatia YD, Ayukawa Y, Furuhashi A, Koyano K. Current barrier membranes: titanium mesh and other membranes for guided bone regeneration in dental applications. J Prosthodont Res 2013; 57: 3-14.10.1016/j.jpor.2012.12.001 ↗
4. 4) Cole BJ, Bostrom MP, Pritchard TL, Sumner DR, Tomin E, Lane JM, et al. Use of bone morphogenetic protein 2 on ectopic porous coated implants in the rat. Clin Orthop Relat Res 1997; 345: 219-228.10.1097/00003086-199712000-00032 ↗
5. 5) Ferretti C, Ripamonti U. Human segmental mandibular defects treated with naturally derived bone morphogenetic proteins. J Craniofac Surg 2002; 13: 434-444.10.1097/00001665-200205000-00014 ↗
6. 6) Ban S, Iwaya Y, Kono H, Sato H. Surface modification of titanium by etching in concentrated sulfuric acid. Dent Mater 2006; 22: 1115-1120.10.1016/j.dental.2005.09.007 ↗
7. 7) Hamouda IM, Enan ET, Al-Wakeel EE, Yousef MK. Alkali and heat treatment of titanium implant material for bioactivity. Int J Oral Maxillofac Implants 2012; 27: 776-784.
8. 8) Iwaya Y, Machigashira M, Kanbara K, Miyamoto M, Noguchi K, Izumi Y, et al. Surface properties and biocompatibility of acid-etched titanium. Dent Mater J 2008; 27: 415-421.10.4012/dmj.27.415 ↗
9. 9) Jemat A, Ghazali MJ, Razali M, Otsuka Y. Surface modifications and their effects on titanium dental implants. Biomed Res Int 2015; 2015: 791725.10.1155/2015/791725 ↗
10. 10) Le Guéhennec L, Soueidan A, Layrolle P, Amouriq Y. Surface treatments of titanium dental implants for rapid osseointegration. Dent Mater 2007; 23: 844-854.10.1016/j.dental.2006.06.025 ↗
11. 11) Offermanns V, Andersen OZ, Riede G, Sillassen M, Jeppesen CS, Almtoft KP, et al. Effect of strontium surface-functionalized implants on early and late osseointegration: A histological, spectrometric and tomographic evaluation. Acta Biomater 2018; 69: 385-394.10.1016/j.actbio.2018.01.049 ↗
12. 12) Shi X, Nakagawa M, Kawachi G, Xu L, Ishikawa K. Surface modification of titanium by hydrothermal treatment in Mg-containing solution and early osteoblast responses. J Mater Sci Mater Med 2012; 23: 1281-1290.10.1007/s10856-012-4596-4 ↗
13. 13) Kokubo T, Miyaji F, Kim HM. Spontaneous formation of bone like apatite layer on chemically treated titanium metals. J Am Ceram Soc 1996; 79: 1127-1129.10.1111/j.1151-2916.1996.tb08561.x ↗
14. 14) Kono H, Miyamoto M, Ban S. Bioactive apatite coating on titanium using an alternate soaking process. Dent Mater J 2007; 26: 186-193.10.4012/dmj.26.186 ↗
15. 15) Kawai T, Takemoto M, Fujibayashi S, Akiyama H, Tanaka M, Yamaguchi S, et al. Osteoinduction on acid and heat treated porous Ti metal samples in canine muscle. PLoS One 2014; 9: e88366.10.1371/journal.pone.0088366 ↗
16. 16) Umehara H, Kobatake R, Doi K, Oki Y, Makihara Y, Kubo T, et al. Histological and bone morphometric evaluation of osseointegration aspects by alkali hydrothermally treated implants. Appl Sci 2018; 8: 635.10.3390/app8040635 ↗
17. 17) Kobatake R, Doi K, Oki Y, Umehara H, Kawano H, Kubo T, et al. Investigation of effective modification treatments for titanium membranes. Appl Sci 2017; 10: 1022.10.3390/app7101022 ↗
18. 18) Camargo WA, Takemoto S, Hoekstra JW, Leeuwenburgh SCG, Jansen JA, van den Beucken JJJP, et al. Effect of surface alkali-based treatment of titanium implants on ability to promote in vitro mineralization and in vivo bone formation. Acta Biomater 2017; 15: 511-523.10.1016/j.actbio.2017.05.016 ↗
19. 19) Nishiguchi S, Fujibayashi S, Kim HM, Kokubo T, Nakamura T.Biology of alkali- and heat-treated titanium implants. J Biomed Mater Res A 2003; 67: 26-35.10.1002/jbm.a.10540 ↗
20. 20) Nishiguchi S, Kato H, Neo M, Oka M, Kim HM, Kokubo T, et al. Alkali- and heat-treated porous titanium for orthopedic implants. J Biomed Mater Res 2001; 54: 198-208.10.1002/1097-4636(200102)54:2<198::AID-JBM6>3.0.CO;2-7 ↗
21. 21) Hatakeyama W, Taira M, Ikeda K, Sato H, Kihira H, Takemoto S, et al. Bone regeneration of rat critical-size calvarial defects using a collagen/porous-apatite composite: micro-CT analyses and histological observations. J Oral Tissue Engin 2017; 15: 49-60.
22. 22) Andrukhov O, Huber R, Shi B, Berner S, Rausch-Fan X, Moritz A, et al. Proliferation, behavior, and differentiation of osteoblasts on surfaces of different microroughness. Dent Mater 2016; 32: 1374-1384.10.1016/j.dental.2016.08.217 ↗
23. 23) Kim HM, Himeno T, Kawashita M, Lee JH, Kokubo T, Nakamura T. Surface potential change in bioactive titanium metal during the process of apatite formation in simulated body fluid. J Biomed Mater Res A 2003; 67: 1305-1309.10.1002/jbm.a.20039 ↗
24. 24) Kokubo T, Pattanayak DK, Yamaguchi S, Takadama H, Matsushita T, Kawai T, et al. Positively charged bioactive Ti metal prepared by simple chemical and heat treatments. J R Soc Interface 2010; 7: 503-513.10.1098/rsif.2010.0129.focus ↗
25. 25) de Oliveira PT, Zalzal SF, Beloti MM, Rosa AL, Nanci A.Enhancement of in vitro osteogenesis on titanium by chemically produced nanotopography. J Biomed Mater Res A 2007; 80: 554-564.10.1002/jbm.a.30955 ↗
26. 26) Yao C, Slamovich EB, Webster TJ. Enhanced osteoblast functions on anodized titanium with nanotube-like structures. J Biomed Mater Res A 2008; 85: 157-166.10.1002/jbm.a.31551 ↗
27. 27) Goldman M, Juodzbalys G, Vilkinis V. Titanium surfaces with nanostructures influence on osteoblasts proliferation: A systematic review. J Oral Maxillofac Res 2014; 5: e1.10.5037/jomr.2014.5301 ↗
28. 28) Karazisis D, Petronis S, Agheli H, Emanuelsson L, Norlindh B, Johansson A, et al. The influence of controlled surface nanotopography on the early biological events of osseointegration. Acta Biomater 2017; 15: 559-571.10.1016/j.actbio.2017.02.026 ↗
29. 29) Mendonça G, Mendonça DB, Aragão FJ, Cooper LF. Advancing dental implant surface technology-From micron-to nanotopography. Biomaterials 2008; 29: 3822-3835.10.1016/j.biomaterials.2008.05.012 ↗
30. 30) Dalby MJ, McCloy D, Robertson M, Wilkinson CD, Oreffo RO. Osteoprogenitor response to defined topographies with nanoscale depths. Biomaterials 2006; 27: 1306-1315.10.1016/j.biomaterials.2005.08.028 ↗