A novel analysis of the formation and resorption changes in dental hard tissue using longitudinal in vivo micro computed tomography
Source abstract
Abstract
This study was to investigate the new analysis manner of dental hard tissue change using in vivo micro-computed tomography (CT) in rat. Scanning, registration, analyzing, and presenting method to track longitudinal in vivo micro-CT data on dental hard tissues were validated in murine models: formative, dentin thickness after direct pulp capping with mineral trioxide aggregate; resorptive, development of apical bone rarefaction in apical periodontitis model. Serial in vivo micro-CT scans were analyzed through rigid-registration, active-contouring, deformable-registration, and motion vector-based quantitative analyses. The rate and direction of hard tissue formation after direct pulp capping was datafied by tracing coordinate shift of fiducial points on pulp chamber outline in formative model. The development of apical periodontitis could be monitored with voxel counts, and quantitatively analyzed in terms of lesion size, bone loss, and mineral density in resorptive model. This study supports the application of longitudinal in vivo micro-CT for resorptive- and formative-phase specific monitoring of dental hard tissues.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Endodontics and Root Canal Treatments · Dental Radiography and Imaging · Drilling and Well Engineering
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Conservative Dentistry and Dental Research Institute, School of Dentistry, Seoul National University
Department of Nuclear and Quantum Engineering, KAIST
References (31)
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