Novel rechargeable calcium phosphate nanoparticle-filled dental cement
Source abstract
Abstract
The objectives were to develop a novel rechargeable cement containing amorphous calcium-phosphate nanoparticles (nanoACP) to suppress tooth decay. Five cements were made with: (1) 60% glass particles (experimental control); (2) 40% glass+20% nanoACP; (3) 30% glass+30% nanoACP; (4) 20% glass+40% nanoACP; (5) 10% glass+50% nanoACP. Groups 1-4 had enamel bond strengths similar to Transbond XT (3M) and Vitremer (3M) (p>0.1). The nanoACP cement had calcium and phosphate ion release which increased with increasing nanoACP fillers. The recharged cement had substantial ion re-release continuously for 14 days after a single recharge. Ion re-release did not decrease with increasing recharge/re-release cycles. Groups 3-5 maintained a safe pH of medium (>5.5); however, control cements had cariogenic pH of medium (<4.5) due to biofilm acid. Therefore, nanoACP cement (1) had good bond strength to enamel, (2) possessed calcium and phosphate ion recharge/re-release capability, and (3) raised biofilm pH to a safe level to inhibit caries.
Source: openalex_inverted_index · Quality: baseline
Research context
OpenAlex topics: Dental materials and restorations · Endodontics and Root Canal Treatments · Dental Implant Techniques and Outcomes
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Orthodontics, School of Stomatology, Capital Medical University
Department of Advanced Oral Sciences and Therapeutics, University of Maryland Dental School
VIP Integrated Department, Stomatological Hospital of Jilin University
Department of Dentistry, China Rehabilitation Research Center
Department of Oral Medicine, School of Stomatology, Zhejiang University
Volpe Research Center, American Dental Association Foundation, National Institute of Standards & Technology
Center for Stem Cell Biology & Regenerative Medicine, University of Maryland School of Medicine
University of Maryland Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine
References (46)
Show source-provided references
1. 1) Øgaard B. White spot lesions during orthodontic treatment: mechanisms and fluoride preventive aspects. Semin Orthod 2008; 14: 183-193.10.1053/j.sodo.2008.03.003 ↗
2. 2) Chapman JA, Roberts WE, Eckert GJ, Kula KS, González-Cabezas C. Risk factors for incidence and severity of white spot lesions during treatment with fixed orthodontic appliances. Am J Orthod Dentofacial Orthop 2010; 138:188-194.10.1016/j.ajodo.2008.10.019 ↗
3. 3) Tufekci E, Dixon JS, Gunsolley J, Lindauer SJ. Prevalence of white spot lesions during orthodontic treatment with fixed appliances. Angle Orthod 2011; 81: 206-210.10.2319/051710-262.1 ↗
4. 4) Richter AE, Arruda AO, Peters MC, Sohn W. Incidence of caries lesions among patients treated with comprehensive orthodontics. Am J Orthod Dentofacial Orthop 2011; 139: 657-664.10.1016/j.ajodo.2009.06.037 ↗
5. 5) Gorton J, Featherstone JD. In vivo inhibition of demineralization around orthodontic brackets. Am J Orthod Dentofacial Orthop 2003; 123: 10-14.10.1067/mod.2003.47 ↗
6. 6) Reynolds EC, Cai F, Cochrane NJ, Shen P, Walker GD, Morgan MV, Reynolds C. Fluoride and casein phosphopeptide-amorphous calcium phosphate. J Dent Res 2008; 87: 344-348.10.1177/154405910808700420 ↗
7. 7) Bailey DL, Adams GG, Tsao CE, Hyslop A, Escobar K, Manton DJ, Reynolds EC, Morgan MV. Regression of post-orthodontic lesions by a remineralizing cream. J Dent Res 2009; 88: 1148-1153.10.1177/0022034509347168 ↗
8. 8) Hamba H, Nikaido T, Inoue G, Sadr A, Tagami J. Effects of CPP-ACP with sodium fluoride on inhibition of bovine enamel demineralization: a quantitative assessment using micro-computed tomography. J Dent 2011; 39: 405-413.10.1016/j.jdent.2011.03.005 ↗
9. 9) Dickens SH, Flaim GM, Takagi S. Mechanical properties and biochemical activity of remineralizing resin-based Ca–PO4 cements. Dent Mater 2003; 19: 558-566.10.1016/S0109-5641(02)00105-7 ↗
10. 10) Regnault WF, Icenogle TB, Antonucci JM, Skrtic D. Amorphous calcium phosphate/urethane methacrylate resin composites. I. Physicochemical characterization. J Mater Sci Mater Med 2008; 19: 507-515.10.1007/s10856-007-3178-3 ↗
11. 11) Skrtic D, Antonucci JM, Eanes ED. Improved properties of amorphous calcium phosphate fillers in remineralizing resin composites. Dent Mater 1996; 12: 295-301.10.1016/S0109-5641(96)80037-6 ↗
12. 12) Langhorst SE, O’Donnell JN, Skrtic D. In vitro remineralization of enamel by polymeric amorphous calcium phosphate composite: quantitative microradiographic study. Dent Mater 2009; 25: 884-891.10.1016/j.dental.2009.01.094 ↗
13. 13) Xu HH, Moreau JL, Sun L, Chow LC. Nanocomposite containing amorphous calcium phosphate nanoparticles for caries inhibition. Dent Mater 2011; 27: 762-769.10.1016/j.dental.2011.03.016 ↗
14. 14) Moreau JL, Sun L, Chow LC, Xu HH. Mechanical and acid neutralizing properties and bacteria inhibition of amorphous calcium phosphate dental nanocomposite. J Biomed Mater Res B 2011; 98: 80-88.10.1002/jbm.b.31834 ↗
15. 15) Weir MD, Chow L, Xu HH. Remineralization of demineralized enamel via calcium phosphate nanocomposite. J Dent Res 2012; 91: 979-984.10.1177/0022034512458288 ↗
16. 16) Melo MAS, Weir MD, Rodrigues LK, Xu HH. Novel calcium phosphate nanocomposite with caries-inhibition in a human in situ model. Dent Mater 2013; 29: 231-240.10.1016/j.dental.2012.10.010 ↗
17. 17) Zhang L, Weir MD, Hack G, Fouad AF, Xu HH. Rechargeable dental adhesive with calcium phosphate nanoparticles for long-term ion release. J Dent 2015; 43: 1587-1595.10.1016/j.jdent.2015.06.009 ↗
18. 18) Zhang L, Weir MD, Chow LC, Antonucci JM, Chen J, Xu HH. Novel rechargeable calcium phosphate dental nanocomposite. Dent Mater 2016; 32: 285-293.10.1016/j.dental.2015.11.015 ↗
19. 19) Boland EJ, MacDougall M, Carnes DL, Dickens SH. In vitro cytotoxicity of a remineralizing resin-based calcium phosphate cement. Dent Mater 2006; 22: 338-345.10.1016/j.dental.2005.05.004 ↗
20. 20) Venz S, Dickens B. Modified surface-active monomers for adhesive bonding to dentin. J Dent Res 1993; 72: 582-586.10.1177/00220345930720030501 ↗
21. 21) Milward PJ, Adusei GO, Lynch CD. Improving some selected properties of dental polyacid-modified composite resins. Dent Mater 2011; 27: 997-1002.10.1016/j.dental.2011.06.006 ↗
22. 22) Skrtic D, Antonucci JM, Liu DW. Ethoxylated bisphenol dimethacrylate-based amorphous calcium phosphate composites. Acta Biomater 2006; 2: 85-94.10.1016/j.actbio.2005.10.004 ↗
23. 23) Uysal T, Amasyali M, Ozcan S, Koyuturk AE, Sagdic D. Effect of antibacterial monomer-containing adhesive on enamel demineralization around orthodontic brackets: An in-vivo study. Am J Orthod Dentofacial Orthop 2011; 139: 650-656.10.1016/j.ajodo.2009.06.038 ↗
24. 24) Melo MA, Wu J, Weir MD, Xu HH. Novel antibacterial orthodontic cement containing quaternary ammonium monomer dimethylaminododecyl methacrylate. J Dent 2014; 42: 1193-1201.10.1016/j.jdent.2014.07.006 ↗
25. 25) Scougall-Vilchis RJ, Yamamoto S, Kitai N, Hotta M. Shear bond strength of a new fluoride-releasing orthodontic adhesive. Dent Mater J 2007; 26: 45-51.10.4012/dmj.26.45 ↗
26. 26) Scougall-Vilchis RJ, Ohashi S, Yamamoto K. Effects of 6 self-etching primers on shear bond strength of orthodontic brackets. Am J Orthod Dentofacial Orthop 2009; 135: 424. e1-424.e7.10.1016/j.ajodo.2008.10.016 ↗
27. 27) Cheng HY, Chen CH, Li CL, Tsai HH, Chou TH, Wang WN. Bond strength of orthodontic light-cured resin-modified glass ionomer cement. Eur J Orthodont 2011; 33: 180-184.10.1093/ejo/cjq056 ↗
28. 28) Poosti M, Ramazanzadeh BA, Zebarjad M, Javadzadeh P, Naderinasab M, Shakeri MT. Shear bond strength and antibacterial effects of orthodontic composite containing TiO2 nanoparticles. Eur J Orthodont 2013; 35: 676-679.10.1093/ejo/cjs073 ↗
29. 29) Tuncer C, Tuncer BB, Ulusoy Ç. Effect of fluoride-releasing light-cured resin on shear bond strength of orthodontic brackets. Am J Orthod Dentofacial Orthop 2009; 135: 14.e1-14.e6.10.1016/j.ajodo.2008.09.016 ↗
30. 30) Akhavan A, Sodagar A, Mojtahedzadeh F, Sodagar K. Investigating the effect of incorporating nanosilver/nanohydroxyapatite particles on the shear bond strength of orthodontic adhesives. Acta Odontol Scand 2013; 71: 1038-1042.10.3109/00016357.2012.741699 ↗
31. 31) Paschos E, Kleinschrodt T, Clementino-Luedemann T, Huth KC, Hickel R, Kunzelmann KH, Rudzki-Janson I. Effect of different bonding agents on prevention of enamel demineralization around orthodontic brackets. Am J Orthod Dentofacial Orthop 2009; 135: 603-612.10.1016/j.ajodo.2007.11.028 ↗
32. 32) Meyer-Lueckel H, Hopfenmuller W, Von Klinggraff D, Kielbassa AM. Microradiographic study on the effects of mucin-based solutions used as saliva substitutes on demineralised bovine enamel in vitro. Arch Oral Biol 2006; 51: 541-547.10.1016/j.archoralbio.2006.01.006 ↗
33. 33) McBain AJ. In vitro biofilm models: an overview. Adv Appl Microbiol 2009; 69: 99-132.10.1016/S0065-2164(09)69004-3 ↗
34. 34) Cheng L, Exterkate RAM, Zhou X, Li J, Ten Cate JM. Effect of Galla chinensis on growth and metabolism of microcosm biofilms. Caries Res 2011; 45: 87-92.10.1159/000324084 ↗
35. 35) McBain AJ, Sissons C, Ledder RG, Sreenivasan PK, Vizio WD, Gilbert P. Development and characterization of a simple perfused oral microcosm. J Appl Microbiol 2005; 98: 624-634.10.1111/j.1365-2672.2004.02483.x ↗
36. 36) Cheng L, Weir MD, Xu HH, Kraigsley AM, Lin NJ, Lin-Gibson S, Zhou X. Antibacterial and physical properties of calcium–phosphate and calcium–fluoride nanocomposites with chlorhexidine. Dent Mater 2012; 28: 573-583.10.1016/j.dental.2012.01.006 ↗
37. 37) Van Landuyt KL, Snauwaert J, De Munck J, Peumans M, Yoshida Y, Poitevin A, Coutinho E, Suzuki K, Lambrechts P, Meerbeek BV. Systematic review of the chemical composition of contemporary dental adhesives. Biomaterials 2007; 28: 3757-3785.10.1016/j.biomaterials.2007.04.044 ↗
38. 38) Pashley DH, Tay FR, Carvalho RM, Rueggeberg FA, Agee KA, Carrilho M, Donnelly A, Garcia-Godoy F. From dry bonding to water-wet bonding to ethanol-wet bonding. A review of the interactions between dentin matrix and solvated resins using a macromodel of the hybrid layer. Am J Dent 2007; 20: 7-21.
39. 39) Finer Y, Santerre JP. The influence of resin chemistry on a dental composite’s biodegradation. J Biomed Mater Res A 2004; 69: 233-246.10.1002/jbm.a.30000 ↗
40. 40) Takahashi M, Nakajima M, Hosaka K, Ikeda M, Foxton RM, Tagami J. Long-term evaluation of water sorption and ultimate tensile strength of HEMA-containing/-free one-step self-etch adhesives. J Dent 2011; 39: 506-512.10.1016/j.jdent.2011.04.008 ↗
41. 41) Xu X, Burgess JO. Compressive strength, fluoride release and recharge of fluoride-releasing materials. Biomaterials 2003; 24: 2451-2461.10.1016/S0142-9612(02)00638-5 ↗
42. 42) Ahn SJ, Lee SJ, Lee DY, Lim BS. Effects of different fluoride recharging protocols on fluoride ion release from various orthodontic adhesives. J Dent 2011; 39: 196-201.10.1016/j.jdent.2010.12.003 ↗
43. 43) Naoum S, Ellakwa A, Martin F, Swain M. Fluoride release, recharge and mechanical property stability of various fluoride-containing resin composites. Oper Dent 2011; 36: 422-432.10.2341/10-414-L ↗
44. 44) Featherstone JDB. The continuum of dental caries –Evidence for a dynamic disease process. J Dent Res 2004; 83 (Suppl): 39-42.10.1177/154405910408301s08 ↗
45. 45) Thylstrup A, Fejerskov O. Textbook of cariology. Copenhagen: Munksgaard, 1986; 145-146.
46. 46) Dawes C. What is the critical pH and why does a tooth dissolve in acid? J Can Dent Assoc 2003; 69: 722-724.