Materials approaches for modulating neural tissue responses to implanted microelectrodes through mechanical and biochemical means
Source abstract
Abstract
Implantable intracortical microelectrodes face an uphill struggle for widespread clinical use. Their potential for treating a wide range of traumatic and degenerative neural disease is hampered by their unreliability in chronic settings. A major factor in this decline in chronic performance is a reactive response of brain tissue, which aims to isolate the implanted device from the rest of the healthy tissue. In this review we present a discussion of materials approaches aimed at modulating the reactive tissue response through mechanical and biochemical means. Benefits and challenges associated with these approaches are analyzed, and the importance of multimodal solutions tested in emerging animal models are presented.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Neuroscience and Neural Engineering · Conducting polymers and applications · Electrochemical sensors and biosensors
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (100+)
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1. Conducting-polymer nanotubes for controlled drug release10.1002/adma.200501726 ↗
2. Multifunctional nanobiomaterials for neural interfaces10.1002/adfm.200801473 ↗
3. Agha NS, Komar J, Yin M, Borton DA, Nurmikko A. A fully wireless platform for correlating behavior and neural data from an implanted, neural recording device: demonstration in a freely moving swine model. In: Neural engineering (NER), 2013 6th international IEEE/EMBS conference on, 2013. p. 989–2.
4. Deep brain stimulation for treatment-resistant depression: efficacy, safety and mechanisms of action10.1016/j.neubiorev.2012.06.001 ↗
5. Seeding neural progenitor cells on silicon-based neural probes10.3171/2010.1.JNS09313 ↗
6. The surface immobilization of the neural adhesion molecule L1 on neural probes and its effect on neuronal density and gliosis at the probe/tissue interface10.1016/j.biomaterials.2010.09.033 ↗
7. Surface immobilization of neural adhesion molecule L1 for improving the biocompatibility of chronic neural probes: in vitro characterization10.1016/j.actbio.2008.02.028 ↗
8. Failure mode analysis of silicon-based intracortical microelectrode arrays in non-human primates10.1088/1741-2560/10/6/066014 ↗
9. Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson’s disease10.1016/S1474-4422(08)70291-6 ↗
10. Interaction of macrophages with fibrous materials in vitro10.1016/0142-9612(96)00014-2 ↗
11. Nucleus accumbens deep brain stimulation decreases ratings of depression and anxiety in treatment-resistant depression10.1016/j.biopsych.2009.09.013 ↗
12. Neuronal cell loss accompanies the brain tissue response to chronically implanted silicon microelectrode arrays10.1016/j.expneurol.2005.04.020 ↗
13. The brain tissue response to implanted silicon microelectrode arrays is increased when the device is tethered to the skull10.1002/jbm.a.31138 ↗
14. Deep brain stimulation for pain relief: a meta-analysis10.1016/j.jocn.2004.10.005 ↗
15. A MRI-compatible stereotaxic localizer box enables high-precision stereotaxic procedures in pigs10.1016/j.jneumeth.2004.05.004 ↗
16. Effects of insertion conditions on tissue strain and vascular damage during neuroprosthetic device insertion10.1088/1741-2560/3/3/002 ↗
17. A flexible perforated microelectrode array for extended neural recordings10.1109/10.108125 ↗
18. Behavioral recovery from spinal cord injury following delayed application of polyethylene glycol10.1242/jeb.205.1.1 ↗
19. Borton D, Yin M, Aceros J, Agha N, Minxha J, Komar J, Patterson W, Bull C, Nurmikko A. Developing implantable neuroprosthetics: a new model in pig. In: Engineering in medicine and biology society, EMBC, 2011 annual international conference of the IEEE, 2011. p. 3024–30.
20. Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues10.1001/archneurol.2010.260 ↗
21. Sources and effects of electrode impedance during deep brain stimulation10.1016/j.clinph.2005.10.007 ↗
22. Poly-HEMA as a drug delivery device for in vitro neural networks on micro-electrode arrays10.1088/1741-2560/2/4/007 ↗
23. Synthesis and characterization of glucocorticoid functionalized poly (N-vinyl pyrrolidone): a versatile prodrug for neural interface10.1021/bm100095t ↗
24. Three-dimensional flexible microprobe for recording the neural signal10.1117/1.3455409 ↗
25. A multichannel neural probe for selective chemical delivery at the cellular level10.1109/10.605435 ↗
26. Deep brain stimulation for chronic pain: results of two multicenter trials and a structured review10.1046/j.1526-4637.2001.01029.x ↗
27. Cui XT, Lee VA, Raphael Y, Wiler JA, Hetke JF, Anderson DJ, Martin DC. Surface modification of neural recording electrodes with conducting polymer/biomolecule blends. J Biomed Mater Res 2001; 56: 261–272. .10.1002/1097-4636(200108)56:2<261::AID-JBM1094>3.0.CO;2-I ↗
28. In vivo studies of polypyrrole/peptide coated neural probes10.1016/S0142-9612(02)00415-5 ↗
29. Collagen-dependent neurite outgrowth and response to dynamic deformation in three-dimensional neuronal cultures10.1007/s10439-007-9292-z ↗
30. Factors influencing the biocompatibility of insertable siliconmicroshafts in cerebral cortex10.1109/10.141202 ↗
31. Matrices with compliance comparable to that of brain tissue select neuronal over glial growth in mixed cortical cultures10.1529/biophysj.105.073114 ↗
32. Brain micromotion around implants in the rodent somatosensory cortex10.1088/1741-2560/3/3/001 ↗
33. Visualization of the visual cortex in minipigs using fMRI10.1016/j.rvsc.2006.08.004 ↗
34. Mechanical factors in the design of chronic recording intracortical microelectrodes10.1109/TBME.1973.324190 ↗
35. Electrical activation of spinal neural circuits: application to motor-system neural prostheses10.1046/j.1525-1403.2000.00097.x ↗
36. Hara SA, Kim BJ, Kuo JTW, Lee CD, Gutierrez CA, Hoang T, Pikov V, Meng E. Perforated 2x2 parylene sheath electrode array for chronic intracortical recording. In: Neural engineering (NER), 2013 6th international IEEE/EMBS conference on, 2013. p. 645–8.10.1109/NER.2013.6696017 ↗
37. Mechanically adaptive intracortical implants improve the proximity of neuronal cell bodies10.1088/1741-2560/8/6/066011 ↗
38. In vivo deployment of mechanically adaptive nanocomposites for intracortical microelectrodes10.1088/1741-2560/8/4/046010 ↗
39. Biological, mechanical, and technological considerations affecting the longevity of intracortical electrode recordings10.1615/CritRevBiomedEng.2014010788 ↗
40. He W, Bellamkonda RV. Indwelling neural implants. In: Reichert WM, editor. Frontiers in neuroengineering. CRC; 2008. p. 151–175.10.1201/9781420009309.pt4 ↗
41. Nanoscale neuro-integrative coatings for neural implants10.1016/j.biomaterials.2004.08.021 ↗
42. Nanoscale laminin coating modulates cortical scarring response around implanted silicon microelectrode arrays10.1088/1741-2560/3/4/009 ↗
43. A novel anti-inflammatory surface for neural electrodes10.1002/adma.200700943 ↗
44. Postmortem analysis of bilateral subthalamic electrode implants in Parkinson’s disease10.1002/mds.1261 ↗
45. Development of a stimuli-responsive polymer nanocomposite toward biologically optimized, MEMS-based neural probes10.1088/0960-1317/21/5/054009 ↗
46. Implanted neural interfaces10.1093/acprof:oso/9780195389784.003.0017 ↗
47. Neuronal ensemble control of prosthetic devices by a human with tetraplegia10.1038/nature04970 ↗
48. Hydrogels for biomedical applications10.1016/S0169-409X(01)00239-3 ↗
49. Hydrogels for biomedical applications10.1016/j.addr.2012.09.010 ↗
50. An unusual inflammatory response to implanted deep brain electrodes10.1017/S0317167100120840 ↗
51. Causes and prevalence of visual impairment among adults in the United States10.1001/archopht.122.4.477 ↗
52. Aligned microcontact printing of micrometer-scale poly-L-lysine structures for controlled growth of cultured neurons on planar microelectrode arrays10.1109/10.817614 ↗
53. Peptide ormosils as cellular substrates10.1039/b705393b ↗
54. Sol–gel derived materials as substrates for neuronal differentiation: effects of surface features and protein conformation10.1039/b602008a ↗
55. Surface analysis by X-ray photoelectron spectroscopy of sol–gel silica modified with covalently bound peptides10.1021/jp0744230 ↗
56. Release of nerve growth factor from HEMA hydrogel-coated substrates and its effect on the differentiation of neural cells10.1021/bm801101e ↗
57. A patient with a resistant major depression disorder treated with deep brain stimulation in the inferior thalamic peduncle10.1227/01.NEU.0000170434.44335.19 ↗
58. Preferential glial cell attachment to microcontact printed surfaces10.1016/S0165-0270(97)00069-1 ↗
59. Repeated voltage biasing improves unit recordings by reducing resistive tissue impedances10.1109/TNSRE.2005.847373 ↗
60. Selective adhesion of astrocytes to surfaces modified with immobilized peptides10.1016/S0142-9612(01)00133-8 ↗
61. The upregulation of specific interleukin (IL) receptor antagonists and paradoxical enhancement of neuronal apoptosis due to electrode induced strain and brain micromotion10.1016/j.biomaterials.2012.05.021 ↗
62. Relationship between intracortical electrode design and chronic recording function10.1016/j.biomaterials.2013.07.016 ↗
63. Hydrogel mediated delivery of trophic factors for neural repair10.1002/wnan.10 ↗
64. Mechanosensitive TRPC1 channels promote calpain proteolysis of talin to regulate spinal axon outgrowth10.1523/JNEUROSCI.2142-12.2013 ↗
65. Conducting polymers grown in hydrogel scaffolds coated on neural prosthetic devices10.1002/jbm.a.30124 ↗
66. Sustained release of dexamethasone from hydrophilic matrices using PLGA nanoparticles for neural drug delivery10.1016/j.biomaterials.2005.12.021 ↗
67. Conducting polymers on hydrogel-coated neural electrode provide sensitive neural recordings in auditory cortex10.1016/j.actbio.2009.07.034 ↗
68. A hybrid silicon-parylene neural probe with locally flexible regions
69. Chronic response of adult rat brain tissue to implants anchored to the skull10.1016/j.biomaterials.2003.09.010 ↗
70. Polyethylene glycol treatment after traumatic brain injury reduces beta-amyloid precursor protein accumulation in degenerating axons10.1002/jnr.20837 ↗
71. Behavioral recovery from traumatic brain injury after membrane reconstruction using polyethylene glycol10.1186/1754-1611-2-9 ↗
72. Intravenous polyethylene glycol inhibits the loss of cerebral cells after brain injury10.1089/neu.2005.22.1092 ↗
73. Insertion shuttle with carboxyl terminated self-assembled monolayer coatings for implanting flexible polymer neural probes in the brain10.1016/j.jneumeth.2009.08.002 ↗
74. Ultrasmall implantable composite microelectrodes with bioactive surfaces for chronic neural interfaces10.1038/nmat3468 ↗
75. Neurite outgrowth and branching of PC12 cells on very soft substrates sharply decreases below a threshold of substrate rigidity10.1088/1741-2560/4/2/003 ↗
76. Biomechanical analysis of silicon microelectrode-induced strain in the brain10.1088/1741-2560/2/4/003 ↗
77. Polyimide based neural implants with stiffness improvement10.1016/j.snb.2003.10.018 ↗
78. In vivo impedance spectroscopy of deep brain stimulation electrodes10.1088/1741-2560/6/4/046001 ↗
79. The auditory midbrain implant: a new auditory prosthesis for neural deafness-concept and device description10.1097/01.mao.0000232010.01116.e9 ↗
80. Anti-acrolein treatment improves behavioral outcome and alleviates myelin damage in experimental autoimmune enchephalomyelitis mouse10.1016/j.neuroscience.2010.11.018 ↗
81. Treatment of chronic pain by deep brain stimulation: long term follow-up and review of the literature10.1227/00006123-198712000-00017 ↗
82. Ultrafast resorbing polymers for use as carriers for cortical neural probes10.1016/j.actbio.2011.02.027 ↗
83. The density difference between tissue and neural probes is a key factor for glial scarring
84. Gelatine-embedded electrodes—a novel biocompatible vehicle allowing implantation of highly flexible microelectrodes10.1088/1741-2560/7/4/046005 ↗
85. The use of pigs in neuroscience: modeling brain disorders10.1016/j.neubiorev.2007.02.003 ↗
86. Cochlear prosthetics10.1146/annurev.ne.13.030190.002041 ↗
87. Deep brain stimulation for Parkinson’s disease: disrupting the disruption10.1016/S1474-4422(02)00101-1 ↗
88. Subcallosal cingulate gyrus deep brain stimulation for treatment-resistant depression10.1016/j.biopsych.2008.05.034 ↗
89. Poly(3,4-ethylenedioxythiophene) (PEDOT) polymer coatings facilitate smaller neural recording electrodes10.1088/1741-2560/8/1/014001 ↗
90. Chronic neural recordings using silicon microelectrode arrays electrochemically deposited with a poly(3,4-ethylenedioxythiophene) (PEDOT) film10.1088/1741-2560/3/1/007 ↗
91. Polyethylene glycol immediately repairs neuronal membranes and inhibits free radical production after acute spinal cord injury10.1046/j.1471-4159.2002.01160.x ↗
92. Deep brain stimulation of the ventral capsule/ventral striatum for treatment-resistant depression10.1016/j.biopsych.2008.08.029 ↗
93. Sub-meninges implantation reduces immune response to neural implants10.1016/j.jneumeth.2013.01.020 ↗
94. In vitro assessment of bioactive coatings for neural implant applications10.1002/jbm.a.20009 ↗
95. Robust penetrating microelectrodes for neural interfaces realized by titanium micromachining10.1007/s10544-011-9519-5 ↗
96. Simultaneous recording of rat auditory cortex and thalamus via a titanium-based, microfabricated, microelectrode device10.1088/1741-2560/8/4/046007 ↗
97. Impedance characterization of microarray recording electrodes in vitro
98. Flexible polyimide probes with microelectrodes and embedded microfluidic channels for simultaneous drug delivery and multi-channel monitoring of bioelectric activity10.1016/j.bios.2003.11.021 ↗
99. The societal costs of severe to profound hearing loss in the United States10.1017/S0266462300103162 ↗
100. Electron microscopy of tissue adherent to explanted electrodes in dystonia and Parkinson’s disease10.1093/brain/awh292 ↗