Mechanogenomic coupling of lung tissue stiffness, EMT and coronavirus pathogenicity
Source abstract
Abstract
In this Current Opinion, we highlight the importance of the material properties of tissues and how alterations therein, which influence epithelial-to-mesenchymal transitions, represent an important layer of regulation in a number of diseases and potentially also play a critical role in host-pathogen interactions. In light of the current SARS-CoV-2 pandemic, we here highlight the possible role of lung tissue stiffening with ageing and how this might facilitate increased SARS-CoV-2 replication through matrix-stiffness dependent epithelial-to-mesenchymal transitions of the lung epithelium. This emphasizes the need for integrating material properties of tissues in drug discovery programs.
Source: europepmc · Quality: candidate unverified · Source record ↗
Research context
OpenAlex topics: Cancer Cells and Metastasis · Biomarkers in Disease Mechanisms · Fibroblast Growth Factor Research
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
References (31)
Show source-provided references
1. Human coronavirus: Host-pathogen interaction10.1146/annurev-micro-020518-115759 ↗
2. Estimating clinical severity of COVID-19 from the transmission dynamics in Wuhan, China10.1038/s41591-020-0822-7 ↗
3. Drug repurposing: progress, challenges and recommendations10.1038/nrd.2018.168 ↗
4. The mechanobiology of aging10.1146/annurev-bioeng-071114-040829 ↗
5. How the ageing microenvironment influences tumour progression10.1038/s41568-019-0222-9 ↗
6. Matrix modeling and remodeling: a biological interplay regulating tissue homeostasis and diseases10.1016/j.matbio.2018.08.007 ↗
7. Matrix rigidity regulates a switch between TGF-β1–induced apoptosis and epithelial–mesenchymal transition10.1091/mbc.e11-06-0537 ↗
8. Rice, A. J., Cortes, E., Lachowski, D., Cheung, B. C. H., Karim, S. A., Morton, J. P., Del Rio Hernandez, A., 2017. Matrix stiffness induces epithelial–mesenchymal transition and promotes chemoresistance in pancreatic cancer cells. Oncogenesis, 6(7), e352–e352.10.1038/oncsis.2017.54 ↗
9. Epithelial cells: liaisons of immunity10.1016/j.coi.2019.11.004 ↗
10. The hallmarks of fibroblast ageing10.1016/j.mad.2014.03.004 ↗
11. Aging and anatomical variations in lung tissue stiffness10.1152/ajplung.00415.2017 ↗
12. An atlas of the aging lung mapped by single cell transcriptomics and deep tissue proteomics10.1038/s41467-019-08831-9 ↗
13. EMT: when epithelial cells decide to become mesenchymal-like cells10.1172/JCI39675 ↗
14. The epigenetics of epithelial-mesenchymal plasticity in cancer10.1038/nm.3336 ↗
15. Mechanical control of epithelial-to-mesenchymal transitions in development and cancer10.1146/annurev-cellbio-111315-125150 ↗
16. The physics of cellular decision making during epithelial-mesenchymal transition10.1146/annurev-biophys-121219-081557 ↗
17. Fibroblasts: the arbiters of extracellular matrix remodeling10.1016/j.matbio.2020.05.006 ↗
18. Lung extracellular matrix and fibroblast function10.1513/AnnalsATS.201406-240MG ↗
19. PU. 1 controls fibroblast polarization and tissue fibrosis10.1038/s41586-019-0896-x ↗
20. Shared and distinct mechanisms of fibrosis10.1038/s41584-019-0322-7 ↗
21. Regulation of genome organization and gene expression by nuclear mechanotransduction10.1038/nrm.2017.101 ↗
22. Matrix mechanosensing: from scaling concepts in’omics data to mechanisms in the nucleus, regeneration, and cancer10.1146/annurev-biophys-062215-011206 ↗
23. Cell geometric constraints induce modular gene-expression patterns via redistribution of HDAC3 regulated by actomyosin contractility10.1073/pnas.1300801110 ↗
24. Orientation and repositioning of chromosomes correlate with cell geometry–dependent gene expression10.1091/mbc.e16-12-0825 ↗
25. Chromosome intermingling: mechanical hotspots for genome regulation10.1016/j.tcb.2017.06.005 ↗
26. Compressive force induces reversible chromatin condensation and cell geometry–dependent transcriptional response10.1091/mbc.E18-04-0256 ↗
27. Cell geometry dictates TNFα-induced genome response10.1073/pnas.1618007114 ↗
28. Spagnolo, P., Balestro, E., Aliberti, S., Cocconcelli, E., Biondini, D., Della Casa, G., Sverzellati, N., & Maher, T. M. (2020). Pulmonary fibrosis secondary to COVID-19: a call to arms? The Lancet Respiratory Medicine.10.1016/S2213-2600(20)30222-8 ↗
29. The NF-κB-dependent and-independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells10.1371/journal.ppat.1006286 ↗
30. Mechano-genomic regulation of coronaviruses and its interplay with ageing10.1038/s41580-020-0242-z ↗
31. Belyaeva, A., Cammarata, L., Radhakrishnan, A., Squires, C., Yang, K. D., Shivashankar, G. V., & Uhler, C. (2020). Causal network models of SARS-CoV-2 expression and aging to identify candidates for drug repurposing. arXiv- 2006.03735 (https://arxiv.org/abs/2006.03735).10.1038/s41467-021-21056-z ↗