DataVXAdvanced Functional MaterialsPaper
journal article·2020-08Open access

Graphene Oxide‐Cyclic R10 Peptide Nuclear Translocation Nanoplatforms for the Surmounting of Multiple‐Drug Resistance

Zhaoxu Tu, Ievgen S. Donskyi, Haishi Qiao, Zhonglin Zhu, Wolfgang E. S. Unger, Christian P. R. Hackenberger, Wei Chen, Mohsen Adeli, Rainer Haag

Advanced Functional Materials· Volume 30· Issue 35
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Source abstract

Abstract

Abstract Multidrug resistance resulting from a variety of defensive pathways in cancer has become a global concern with a considerable impact on the mortality associated with the failure of traditional chemotherapy. Therefore, further research and new therapies are required to overcome this challenge. In this work, a cyclic R10 peptide (cR10) is conjugated to polyglycerol‐covered nanographene oxide to engineer a nanoplatform for the surmounting of multidrug resistance. The nuclear translocation of the nanoplatform, facilitated by cR10 peptide, and subsequently, a laser‐triggered release of the loaded doxorubicin result in efficient anticancer activity confirmed by both in vitro and in vivo experiments. The synthesized nanoplatform with a combination of different features, including active nucleus‐targeting, high‐loading capacity, controlled release of cargo, and photothermal property, provides a new strategy for circumventing multidrug resistant cancers.
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Research context

Nanomaterials

OpenAlex topics: Graphene and Nanomaterials Applications · Graphene research and applications · Advanced biosensing and bioanalysis techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Pharmaceutical Engineering School of Engineering China Pharmaceutical University Nanjing 210009 China

Institut für Chemie und Biochemie Freie Universität Berlin Takustr. 3 Berlin 14195 Germany

BAM – Federal Institute for Material Science and Testing Division 6.1 Surface Analysis and Interfacial Chemistry Unter den Eichen 44–46 Berlin 12205 Germany

Department of Chemical Biology Leibniz‐Forschungsinstitut für Molekulare Pharmakologie (FMP) Robert‐Rössle‐Strasse 10 Berlin 13125 Germany

Humboldt Universität zu Berlin Institut für Chemie Brook‐Taylor‐Str. 2 Berlin 12489 Germany

Department of Chemistry Faculty of Science Lorestan University Khorramabad 68151‐44316 Iran

Funding

National Natural Science Foundation of China · Natural Science Foundation of Jiangsu Province · Fundamental Research Funds for the Central Universities

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